目的:探讨信迪利单抗药物不良反应(adverse drug reaction,ADR)发生的特点及规律,为临床合理用药提供参考。方法:检索中国知网、万方、维普、PubMed和Web of Science数据库,检索截至2021年12月关于信迪利单抗ADRs报道的文献,并对检索到...目的:探讨信迪利单抗药物不良反应(adverse drug reaction,ADR)发生的特点及规律,为临床合理用药提供参考。方法:检索中国知网、万方、维普、PubMed和Web of Science数据库,检索截至2021年12月关于信迪利单抗ADRs报道的文献,并对检索到的文献进行统计分析。结果:共纳入33篇信迪利单抗所致ADR个案报道,涉及患者33例,其中男24例(72.73%),女9例(27.27%);多数患者年龄≥60岁(57.58%);原发疾病以肺癌最多(45.45%);ADR发生时间多为用药1~6个周期以后(84.85%);累及多个系统/器官,以内分泌系统(24.04%)、消化系统(16.67%)、心血管系统(11.11%)和神经系统(11.11%)为主;停药和(或)治疗后好转21例,留下后遗症7例,死亡5例。结论:信迪利单抗少数严重ADRs可导致致命后果,临床使用时应加强用药监护,做到及时对症处理,减少严重ADR的发生。展开更多
As epoxy functional group has high anticancer activity, α, β-epoxyketones were designed and synthesized as new anticancer agents, and their structures were confirmed by UV, 1H NMR, IR, MS technigeces and elemental a...As epoxy functional group has high anticancer activity, α, β-epoxyketones were designed and synthesized as new anticancer agents, and their structures were confirmed by UV, 1H NMR, IR, MS technigeces and elemental analysis. Their in vitro anticancer activities were evaluated by MTF method and the results showed that the compound 4c exhibited good activity with IC50 of 17.8, 22.0 and 24.1 μg/mL against A-549, Hela and HepG2 cells, respectively. The dose of LD50 of the mice by intragastric administration was 1864.4 mg/kg. Therefore, the α, β-epoxyketones could potentially provide as new anticancer agents.展开更多
文摘目的:探讨信迪利单抗药物不良反应(adverse drug reaction,ADR)发生的特点及规律,为临床合理用药提供参考。方法:检索中国知网、万方、维普、PubMed和Web of Science数据库,检索截至2021年12月关于信迪利单抗ADRs报道的文献,并对检索到的文献进行统计分析。结果:共纳入33篇信迪利单抗所致ADR个案报道,涉及患者33例,其中男24例(72.73%),女9例(27.27%);多数患者年龄≥60岁(57.58%);原发疾病以肺癌最多(45.45%);ADR发生时间多为用药1~6个周期以后(84.85%);累及多个系统/器官,以内分泌系统(24.04%)、消化系统(16.67%)、心血管系统(11.11%)和神经系统(11.11%)为主;停药和(或)治疗后好转21例,留下后遗症7例,死亡5例。结论:信迪利单抗少数严重ADRs可导致致命后果,临床使用时应加强用药监护,做到及时对症处理,减少严重ADR的发生。
基金Project supported by the National Natural Science Foundation of China （Nos. 20375010, 20675084）, the Hebei Province Programs for Science and Technology Development （Nos. 06276479B, 07276407D）, Key Laboratory for Pharmaceutical Quality Control of Hebei Province Fund （No. 09265631 D-14） and Hebei University Found （No. 2010Q33）.
文摘As epoxy functional group has high anticancer activity, α, β-epoxyketones were designed and synthesized as new anticancer agents, and their structures were confirmed by UV, 1H NMR, IR, MS technigeces and elemental analysis. Their in vitro anticancer activities were evaluated by MTF method and the results showed that the compound 4c exhibited good activity with IC50 of 17.8, 22.0 and 24.1 μg/mL against A-549, Hela and HepG2 cells, respectively. The dose of LD50 of the mice by intragastric administration was 1864.4 mg/kg. Therefore, the α, β-epoxyketones could potentially provide as new anticancer agents.
