骨髓瘤过表达基因(Myeloma overexpressed gene, MYEOV)近年来在肿瘤研究中受到广泛关注。MYEOV在多种恶性肿瘤中高表达,能够激活TGF-β、TNF、NF-κB等信号通路,促进肿瘤细胞的侵袭、增殖及迁移等,在促癌方面发挥关键作用。MYEOV还参...骨髓瘤过表达基因(Myeloma overexpressed gene, MYEOV)近年来在肿瘤研究中受到广泛关注。MYEOV在多种恶性肿瘤中高表达,能够激活TGF-β、TNF、NF-κB等信号通路,促进肿瘤细胞的侵袭、增殖及迁移等,在促癌方面发挥关键作用。MYEOV还参与肿瘤微环境的构建,与细胞免疫密切相关。尽管该基因与肿瘤发病密切相关,但MYEOV介导肿瘤发生的分子机制、蛋白表达及免疫相关性仍不明确,因此我们将MYEOV在不同肿瘤中的生物学过程及促癌机制等方面进行总结,并探讨了MYEOV与肿瘤微环境和免疫系统的关系,为肿瘤的治疗提供新的思路。Myeloma overexpressed gene (MYEOV) has attracted widespread attention in recent tumor research. MYEOV is highly expressed in multiple malignancies and can activate signaling pathways such as TGF-β, TNF and NF-κB, promoting the invasion, proliferation, and migration of tumor cells, playing a key role in carcinogenesis. MYEOV is also involved in the construction of the tumor microenvironment and is closely related to cellular immunity. Although the gene is closely related to tumorigenesis, the molecular mechanism, protein expression, and immune correlation mediated by MYEOV in tumorigenesis are still unclear. Therefore, we summarize the biological processes and carcinogenic mechanisms of MYEOV in different tumors, and discuss the relationship between MYEOV and the tumor microenvironment and the immune system, providing new ideas for tumor treatment.展开更多
文摘骨髓瘤过表达基因(Myeloma overexpressed gene, MYEOV)近年来在肿瘤研究中受到广泛关注。MYEOV在多种恶性肿瘤中高表达,能够激活TGF-β、TNF、NF-κB等信号通路,促进肿瘤细胞的侵袭、增殖及迁移等,在促癌方面发挥关键作用。MYEOV还参与肿瘤微环境的构建,与细胞免疫密切相关。尽管该基因与肿瘤发病密切相关,但MYEOV介导肿瘤发生的分子机制、蛋白表达及免疫相关性仍不明确,因此我们将MYEOV在不同肿瘤中的生物学过程及促癌机制等方面进行总结,并探讨了MYEOV与肿瘤微环境和免疫系统的关系,为肿瘤的治疗提供新的思路。Myeloma overexpressed gene (MYEOV) has attracted widespread attention in recent tumor research. MYEOV is highly expressed in multiple malignancies and can activate signaling pathways such as TGF-β, TNF and NF-κB, promoting the invasion, proliferation, and migration of tumor cells, playing a key role in carcinogenesis. MYEOV is also involved in the construction of the tumor microenvironment and is closely related to cellular immunity. Although the gene is closely related to tumorigenesis, the molecular mechanism, protein expression, and immune correlation mediated by MYEOV in tumorigenesis are still unclear. Therefore, we summarize the biological processes and carcinogenic mechanisms of MYEOV in different tumors, and discuss the relationship between MYEOV and the tumor microenvironment and the immune system, providing new ideas for tumor treatment.
