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DYNAMIC OBSERVATION ON THE CHANGES OF PLASMA SOMATOSTATIN AND GLUCAGON DURING THE DEVELOPMENT OF CIRRHOSIS AND AFTER PORTACAVAL SHUNTING IN THE CIRRHOTIC RATS
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作者 吴志勇 黄安 +5 位作者 郑忠华 陈聿修 陈治平 邝耀麟 小野慶一 金充 《Medical Bulletin of Shanghai Jiaotong University》 CAS 1992年第1期17-26,共10页
In the present study we observed dynamically and systemically the changes of plasma somatostatin and glucagon in the peripheral and portal vein, and the changes of pancreatic immunopathology in the course of developme... In the present study we observed dynamically and systemically the changes of plasma somatostatin and glucagon in the peripheral and portal vein, and the changes of pancreatic immunopathology in the course of development of cirrhosis induced by CCl<sub>4</sub> and after portacaval shunt (PCS) in the cirrhotic rats as well as investigated their causes and correlationship. The results showed that hyperglucagonemia was caused by spontaneous portosystemic shunting and surgically induced portacaval anastomosis. Moreover, there was much higher level of glucagon in the portal vein with corresponding increase of A cells in PCS rats than those in the controls, indicating that another cause for elevation of glucagon was hypersecretion of pancreatic A cells. Our data demonstrated that both deterioration of liver function and portosystemic shunting might not be responsible for the elevated level of somatostatin in the cirrhotic rats with PCS. However, there was a closed positive correlation between plasma glucagon and somatostatin. Thus it was concluded that hyperglucagonemia stimulated the release of somatostatin. In view of the fact the elevated level of glucagon was much higher than that of somatostatin, there was probably a relative lack of somatostatin in cirrhosis with portal hypertension. 展开更多
关键词 SOMATOSTATIN GLUCAGON pancreatic IMMUNOPATHOLOGY CIRRHOSIS of LIVER portal hypertension portacaval SHUNT deterioration of LIVER function
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THE RELATIONSHIP BETWEEN HEPATIC PATHOLOGIC CHANGES AND PORTAL VENOUS PRESSURE DURING DEVELOPMENT OF CIRRHOSIS IN RATS
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作者 吴志勇 黄安 +4 位作者 郑忠华 陈治平 邝耀麟 小野慶一 金充 《Medical Bulletin of Shanghai Jiaotong University》 CAS 1991年第1期14-22,共9页
In order to pinpoint the site causing increased intrahepatic vascular resistance, we observed the relationship between hepatic pathologic changes and free portal pressurre (FPP) during the development of CCl<sub&... In order to pinpoint the site causing increased intrahepatic vascular resistance, we observed the relationship between hepatic pathologic changes and free portal pressurre (FPP) during the development of CCl<sub>4</sub>-induced liver cirrhosis of rat. The results suggested that the degeneration necrosis and regeneration of liver cells, and consequent stenosis, or obliteration of sinusoidal spaces caused by the swelling and disarrangement of the liver cell plates led to the occurence of portal hypertension, The possibility of pre-or post-sinusoidal obstruction was excluded by the manifestation of the pathologic lesions. It is the authors’ belief that the exact site of the increased intrahepatic vascular resistance was most likely at the level of hepatic sinusoids. Furthermore, there was certain positive correlation between plasma glucagon concentration and FPP, indicating that glucagon was also involved in the pathogenesis of portal hypertension. 展开更多
关键词 INTRAHEPATIC vascular resistance CIRRHOSIS of liver portal hypertension stenosis of HEPATIC SINUSOIDS plasma GLUCAGON
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鼠肝硬变形成中和门腔分流术后生长抑素和胰高糖素变化的动态观察 被引量:10
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作者 吴志勇 小野庆一 《中华消化杂志》 CAS CSCD 北大核心 1990年第5期251-254,共4页
关键词 肝硬变 门腔分流 生长抑素 IEG
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鼠肝硬变形成中肝脏病理变化和门静脉压力的关系 被引量:2
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作者 吴志勇 小野庆一 《中华外科杂志》 CAS CSCD 北大核心 1990年第3期147-150,共4页
关键词 肝硬变 肝脏病理 门静脉压力
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