近红外漫射光相关断层成像技术(Diffuse Correlation Tomography,DCT)是一种乳腺微血管血流成像的新技术,但成像的空间分辨率不足,高密度光源探测器(Source and Detector,S-D)阵列的布置方式是否可以有效提高DCT空间分辨率目前尚不清楚...近红外漫射光相关断层成像技术(Diffuse Correlation Tomography,DCT)是一种乳腺微血管血流成像的新技术,但成像的空间分辨率不足,高密度光源探测器(Source and Detector,S-D)阵列的布置方式是否可以有效提高DCT空间分辨率目前尚不清楚。为了研究S-D阵列密度对于DCT血流重建图像空间分辨率的影响,设计了3种S-D阵列,密度分别为24、48和96。结合蒙特卡洛仿真和DCT血流图像重建方法,研究了S-D阵列对于2种含有高血流异质物(模拟乳腺恶性肿瘤)的乳腺组织血流重建效果的影响。结果表明,高密度的SD阵列交错排布可以提高DCT血流重建的空间分辨率,可提升临床早期筛查时乳腺恶性肿瘤成像的精确性和稳定性。展开更多
The mean path length(MPL)of photons is a critical parameter to calculate tissue absorption coefficient as well as blood oxygenation using modified Beer-Lambert law,where in the differential path factor(DPF)is often as...The mean path length(MPL)of photons is a critical parameter to calculate tissue absorption coefficient as well as blood oxygenation using modified Beer-Lambert law,where in the differential path factor(DPF)is often assumed as constant over range of tissue absorption.By utilizing the Monte Carlo(MC)simulation of photon migrations in the leg,this study used four approaches to estimate MPL,and compared them with that determined by the MPL definition.The simulation results indicate that the DPF is remarkably affected by tissue absorption,at approximate 10% variation.A linear model is suggested to calculate MPL for measurements of tissue absorption as well as blood oxygenation using modified Beer-Lambert law.展开更多
文摘近红外漫射光相关断层成像技术(Diffuse Correlation Tomography,DCT)是一种乳腺微血管血流成像的新技术,但成像的空间分辨率不足,高密度光源探测器(Source and Detector,S-D)阵列的布置方式是否可以有效提高DCT空间分辨率目前尚不清楚。为了研究S-D阵列密度对于DCT血流重建图像空间分辨率的影响,设计了3种S-D阵列,密度分别为24、48和96。结合蒙特卡洛仿真和DCT血流图像重建方法,研究了S-D阵列对于2种含有高血流异质物(模拟乳腺恶性肿瘤)的乳腺组织血流重建效果的影响。结果表明,高密度的SD阵列交错排布可以提高DCT血流重建的空间分辨率,可提升临床早期筛查时乳腺恶性肿瘤成像的精确性和稳定性。
基金Research Funds from North University of China(No.130087)
文摘The mean path length(MPL)of photons is a critical parameter to calculate tissue absorption coefficient as well as blood oxygenation using modified Beer-Lambert law,where in the differential path factor(DPF)is often assumed as constant over range of tissue absorption.By utilizing the Monte Carlo(MC)simulation of photon migrations in the leg,this study used four approaches to estimate MPL,and compared them with that determined by the MPL definition.The simulation results indicate that the DPF is remarkably affected by tissue absorption,at approximate 10% variation.A linear model is suggested to calculate MPL for measurements of tissue absorption as well as blood oxygenation using modified Beer-Lambert law.