目的探讨人血清淀粉样蛋白A(SAA)与脑梗死急性期认知功能的关系。方法选择山东大学附属省立医院神经内科确诊的脑梗死急性期患者105例,采用简易精神状态检查(MMSE)评估患者认知功能。根据受教育年限不同,将患者分为受教育年数<6年组(...目的探讨人血清淀粉样蛋白A(SAA)与脑梗死急性期认知功能的关系。方法选择山东大学附属省立医院神经内科确诊的脑梗死急性期患者105例,采用简易精神状态检查(MMSE)评估患者认知功能。根据受教育年限不同,将患者分为受教育年数<6年组(n=36)和受教育年数≥6年组(n=69)。分析SAA与各个影响因素的相关性,包括年龄、性别、受教育程度、α2-巨球蛋白(α2-MG)、吸烟和其他脑血管疾病危险因素,以及与M M SE中各个认知领域的相关性。结果受教育年限<6年组患者M M SE评分以及时间和地点定向、短时记忆和图形执行力等认知域评分显著低于受教育年限≥6年组(P<0.05或P<0.01)。认知评估中,时间与地点定向评分在前循环梗死组(n=53)、后循环梗死组(n=44)和全循环梗死组(n=8)之间的分布差异有统计学意义(P<0.05)。Spearman相关性分析表明,SAA与α2-M G水平呈明显正相关(r=0.29,P<0.01);广义线性回归分析显示,SAA与时间和地点定向以及计算能力下降相关(P<0.05或P<0.01)。结论血清SAA水平升高与脑梗死急性期认知功能障碍有关,尤其是时间与地点定向和计算力障碍。展开更多
A 52 MHz Radio Frequency Quadrupole （RFQ） linear accelerator （linac） is designed to serve as an initial structure for the SSC-Linac system （injector into Separated Sector Cyclotron）.The designed injection and ou...A 52 MHz Radio Frequency Quadrupole （RFQ） linear accelerator （linac） is designed to serve as an initial structure for the SSC-Linac system （injector into Separated Sector Cyclotron）.The designed injection and output energy are 3.5 keV/u and 143 keV/u,respectively.The beam dynamics in this RFQ have been studied using a three-dimensional Particle-In-Cell （PIC） code BEAMPATH.Simulation results show that this RFQ structure is characterized by stable values of beam transmission effciency （at least 95%） for both zerocurrent mode and the space charge dominated regime.The beam accelerated in the RFQ has good quality in both transverse and longitudinal directions,and could easily be accepted by Drift Tube Linac （DTL）.The effect of the vane error and that of the space charge on the beam parameters have been studied as well to define the engineering tolerance for RFQ vane machining and alignment.展开更多
文摘目的探讨人血清淀粉样蛋白A(SAA)与脑梗死急性期认知功能的关系。方法选择山东大学附属省立医院神经内科确诊的脑梗死急性期患者105例,采用简易精神状态检查(MMSE)评估患者认知功能。根据受教育年限不同,将患者分为受教育年数<6年组(n=36)和受教育年数≥6年组(n=69)。分析SAA与各个影响因素的相关性,包括年龄、性别、受教育程度、α2-巨球蛋白(α2-MG)、吸烟和其他脑血管疾病危险因素,以及与M M SE中各个认知领域的相关性。结果受教育年限<6年组患者M M SE评分以及时间和地点定向、短时记忆和图形执行力等认知域评分显著低于受教育年限≥6年组(P<0.05或P<0.01)。认知评估中,时间与地点定向评分在前循环梗死组(n=53)、后循环梗死组(n=44)和全循环梗死组(n=8)之间的分布差异有统计学意义(P<0.05)。Spearman相关性分析表明,SAA与α2-M G水平呈明显正相关(r=0.29,P<0.01);广义线性回归分析显示,SAA与时间和地点定向以及计算能力下降相关(P<0.05或P<0.01)。结论血清SAA水平升高与脑梗死急性期认知功能障碍有关,尤其是时间与地点定向和计算力障碍。
基金Supported by National Natural Science Foundation of China (10635090)
文摘A 52 MHz Radio Frequency Quadrupole （RFQ） linear accelerator （linac） is designed to serve as an initial structure for the SSC-Linac system （injector into Separated Sector Cyclotron）.The designed injection and output energy are 3.5 keV/u and 143 keV/u,respectively.The beam dynamics in this RFQ have been studied using a three-dimensional Particle-In-Cell （PIC） code BEAMPATH.Simulation results show that this RFQ structure is characterized by stable values of beam transmission effciency （at least 95%） for both zerocurrent mode and the space charge dominated regime.The beam accelerated in the RFQ has good quality in both transverse and longitudinal directions,and could easily be accepted by Drift Tube Linac （DTL）.The effect of the vane error and that of the space charge on the beam parameters have been studied as well to define the engineering tolerance for RFQ vane machining and alignment.
