The microbiome of females undergoes extensive remodeling during pregnancy, which is likely to have an impact on the health of both mothers and offspring. Nevertheless, large-scale integrated investigations characteriz...The microbiome of females undergoes extensive remodeling during pregnancy, which is likely to have an impact on the health of both mothers and offspring. Nevertheless, large-scale integrated investigations characterizing microbiome dynamics across key body habitats are lacking. Here, we performed an extensive meta-analysis that compiles and analyzes microbiome profiles from >10,000 samples across the gut,vagina, and oral cavity of pregnant women from diverse geographical regions. We have unveiled unexpected variations in the taxonomic, functional, and ecological characteristics of microbial communities throughout the course of pregnancy. The gut microbiota showed distinct trajectories between Western and non-Western populations. The vagina microbiota exhibited fluctuating transitions at the genus level across gestation, while the oral microbiota remained relatively stable. We also identified distinctive microbial signatures associated with prevalent pregnancy-related disorders, including opposite variations in the oral and gut microbiota of patients with gestational diabetes and disrupted microbial networks in preterm birth. This study establishes a comprehensive atlas of the pregnancy microbiome by integrating multidimensional datasets and offers foundational insights into the intricate interplay between microbes and host factors that underlie reproductive health.展开更多
The human gut is a complex ecosystem,inhabited by a diverse range of microorganisms,including bacteria,archaea,fungi,as well as viruses,collectively known as the gut microbiota.These microorganisms interact with each ...The human gut is a complex ecosystem,inhabited by a diverse range of microorganisms,including bacteria,archaea,fungi,as well as viruses,collectively known as the gut microbiota.These microorganisms interact with each other and also with the host,performing multifaceted functions that support the host’s vital life activities[1].The gut microbiota exerts significant influence on numerous physiological processes in the host,including metabolism,immunomodulation,and regulation of nervous system[2,3].Research conducted over the past few decades has demonstrated the importance of maintaining a balanced intestinal microbiota for human health.Dysbiosis of gut microbiota is usually associated with a variety of diseases,such as inflammatory bowel disease(IBD),obesity,diabetes,colorectal cancer,and cardiovascular,as well as neurological and psychiatric disorders,such as anxiety,depression,autism,and Parkinson’s disease[2,4].As our understanding of the gut microbiota continues to improve,conventional gut microbiota-targeted interventions or utilizing engineered bacteria as therapeutic carriers hold great promise in the treatment or alleviation of various intestinal and systemic diseases.展开更多
基金supported by the National Key R&D Program of China (2022YFA1303900, 2021YFA1301000, and 2022YFC2704702)the National Natural Science Foundation of China(32001082, 32025009, and 82271662)+2 种基金Military Innovation Project Special Project (21JSZ06)Shanghai Shen-Kang Hospital Development Center Special Medical Enterprise Integration Innovation Achievements (SHDC2022CRD007)Postdoctoral Fellowship Program of CPSF (GZC20232650)。
文摘The microbiome of females undergoes extensive remodeling during pregnancy, which is likely to have an impact on the health of both mothers and offspring. Nevertheless, large-scale integrated investigations characterizing microbiome dynamics across key body habitats are lacking. Here, we performed an extensive meta-analysis that compiles and analyzes microbiome profiles from >10,000 samples across the gut,vagina, and oral cavity of pregnant women from diverse geographical regions. We have unveiled unexpected variations in the taxonomic, functional, and ecological characteristics of microbial communities throughout the course of pregnancy. The gut microbiota showed distinct trajectories between Western and non-Western populations. The vagina microbiota exhibited fluctuating transitions at the genus level across gestation, while the oral microbiota remained relatively stable. We also identified distinctive microbial signatures associated with prevalent pregnancy-related disorders, including opposite variations in the oral and gut microbiota of patients with gestational diabetes and disrupted microbial networks in preterm birth. This study establishes a comprehensive atlas of the pregnancy microbiome by integrating multidimensional datasets and offers foundational insights into the intricate interplay between microbes and host factors that underlie reproductive health.
基金supported by the National Key R&D Program of China(2022YFA1303900)the National Natural Science Foundation of China(32001082 and 32025009).
文摘The human gut is a complex ecosystem,inhabited by a diverse range of microorganisms,including bacteria,archaea,fungi,as well as viruses,collectively known as the gut microbiota.These microorganisms interact with each other and also with the host,performing multifaceted functions that support the host’s vital life activities[1].The gut microbiota exerts significant influence on numerous physiological processes in the host,including metabolism,immunomodulation,and regulation of nervous system[2,3].Research conducted over the past few decades has demonstrated the importance of maintaining a balanced intestinal microbiota for human health.Dysbiosis of gut microbiota is usually associated with a variety of diseases,such as inflammatory bowel disease(IBD),obesity,diabetes,colorectal cancer,and cardiovascular,as well as neurological and psychiatric disorders,such as anxiety,depression,autism,and Parkinson’s disease[2,4].As our understanding of the gut microbiota continues to improve,conventional gut microbiota-targeted interventions or utilizing engineered bacteria as therapeutic carriers hold great promise in the treatment or alleviation of various intestinal and systemic diseases.
