Ancient DNA(aDNA)techniques have rapidly evolved in the past decade,including the introduction of next-generation sequencing(NGS)techniques,the modification and optimization of various protocols to extract highly degr...Ancient DNA(aDNA)techniques have rapidly evolved in the past decade,including the introduction of next-generation sequencing(NGS)techniques,the modification and optimization of various protocols to extract highly degraded DNA,and the incorporation of these molecules into sequencing libraries[1].Two major milestones are the application of single-stranded DNA library construction protocol and the automation of lab work using liquid handling robots[1].展开更多
2018年,"尼安德特人母亲和丹尼索瓦人父亲的后代基因组"(The genome of the off spring of a Neanderthal mother and a Denisovan father)[1]的研究被Science评选为十大科学突破之一.该研究利用古DNA技术获取了两种古老型人...2018年,"尼安德特人母亲和丹尼索瓦人父亲的后代基因组"(The genome of the off spring of a Neanderthal mother and a Denisovan father)[1]的研究被Science评选为十大科学突破之一.该研究利用古DNA技术获取了两种古老型人类(指生活在约50~4万年前与现代人相近的早期人类,本文主要指尼安德特人和丹尼索瓦人)产生的子一代个体的全基因组信息,还原了一段不为人知的史前人类(泛指包括古老型人类和早期现代人等在史前出现的所有古人类)混血历史.展开更多
Archaeological and ancient DNA studies revealed that Shandong,a multi-culture center in northern coastal China,was home to ancient populations having ancestry related to both northern and southern East Asian populatio...Archaeological and ancient DNA studies revealed that Shandong,a multi-culture center in northern coastal China,was home to ancient populations having ancestry related to both northern and southern East Asian populations.However,the limited temporal and geographical range of previous studies have been insufficient to describe the population history of this region in greater detail.Here,we report the analysis of 86 complete mitochondrial genomes from the remains of 9500 to 1800-year-old humans from12 archaeological sites across Shandong.For samples older than 4600 years before present(BP),we found haplogroups D4,D5,B4 c1,and B5 b2,which are observed in present-day northern and southern East Asians.For samples younger than 4600 BP,haplogroups C(C7 a1 and C7 b),M9(M9 a1),and F(F1 a1,F2 a,and F4 a1)begin to appear,indicating changes in the Shandong maternal genetic structure starting from the beginning of the Longshan cultural period.Within Shandong,the genetic exchange is possible between the coastal and inland regions after 3100 BP.We also discovered the B5 b2 lineage in Shandong populations,with the oldest Bianbian individual likely related to the ancestors of some East Asians and North Asians.By reconstructing a maternal genetic structure of Shandong populations,we provide greater resolution of the population dynamics of the northern coastal East Asia over the past nine thousand years.展开更多
基金supported by the Chinese Academy of Sciences(YSBR-019 and XDB26000000)the National Natural Science Foundation of China(41925009 and T2192950)+4 种基金the Tencent Foundation(through the XPLORER PRIZE)the Howard Hughes Medical Institute(55008731)the Feng Foundation of Biomedical Researchthe Shanghai Qi Zhi Institutesupported by Special research assistants funded project of the Chinese Academy of Sciences。
文摘Ancient DNA(aDNA)techniques have rapidly evolved in the past decade,including the introduction of next-generation sequencing(NGS)techniques,the modification and optimization of various protocols to extract highly degraded DNA,and the incorporation of these molecules into sequencing libraries[1].Two major milestones are the application of single-stranded DNA library construction protocol and the automation of lab work using liquid handling robots[1].
文摘2018年,"尼安德特人母亲和丹尼索瓦人父亲的后代基因组"(The genome of the off spring of a Neanderthal mother and a Denisovan father)[1]的研究被Science评选为十大科学突破之一.该研究利用古DNA技术获取了两种古老型人类(指生活在约50~4万年前与现代人相近的早期人类,本文主要指尼安德特人和丹尼索瓦人)产生的子一代个体的全基因组信息,还原了一段不为人知的史前人类(泛指包括古老型人类和早期现代人等在史前出现的所有古人类)混血历史.
基金supported by the National Natural Science Foundation of China(41672021,41925009,91731303,and 41630102)“Research on the Roots of Chinese Civilization”of Zhengzhou University(XKZDJC202006)+4 种基金the Chinese Academy of Sciences(XDB26000000,XDA1905010,and QYZDB-SSW-DQC003)the Tencent Foundation through the XPLORER PRIZEthe Howard Hughes Medical Institute(55008731)the National Social Science Foundation of China(15CKG013)the Shandong University Multidisciplinary Research and Innovation Team of Young Scholars(2020QNQT018)。
文摘Archaeological and ancient DNA studies revealed that Shandong,a multi-culture center in northern coastal China,was home to ancient populations having ancestry related to both northern and southern East Asian populations.However,the limited temporal and geographical range of previous studies have been insufficient to describe the population history of this region in greater detail.Here,we report the analysis of 86 complete mitochondrial genomes from the remains of 9500 to 1800-year-old humans from12 archaeological sites across Shandong.For samples older than 4600 years before present(BP),we found haplogroups D4,D5,B4 c1,and B5 b2,which are observed in present-day northern and southern East Asians.For samples younger than 4600 BP,haplogroups C(C7 a1 and C7 b),M9(M9 a1),and F(F1 a1,F2 a,and F4 a1)begin to appear,indicating changes in the Shandong maternal genetic structure starting from the beginning of the Longshan cultural period.Within Shandong,the genetic exchange is possible between the coastal and inland regions after 3100 BP.We also discovered the B5 b2 lineage in Shandong populations,with the oldest Bianbian individual likely related to the ancestors of some East Asians and North Asians.By reconstructing a maternal genetic structure of Shandong populations,we provide greater resolution of the population dynamics of the northern coastal East Asia over the past nine thousand years.
