类风湿关节炎骨质发生不可逆性损坏是免疫细胞浸润与成纤维样滑膜细胞增殖的结果,其主要病理特征为滑膜炎与血管翳生成。巨噬细胞作为人体免疫细胞,在类风湿性关节炎中起着重要作用。一方面,免疫稳态的破坏直接诱发全身炎症,巨噬细胞通...类风湿关节炎骨质发生不可逆性损坏是免疫细胞浸润与成纤维样滑膜细胞增殖的结果,其主要病理特征为滑膜炎与血管翳生成。巨噬细胞作为人体免疫细胞,在类风湿性关节炎中起着重要作用。一方面,免疫稳态的破坏直接诱发全身炎症,巨噬细胞通过与成纤维细胞样滑膜细胞的相互作用引发并延续滑膜炎和组织损伤;另一方面,巨噬细胞的极化在类风湿关节炎发展过程中起着促炎及抗炎双重作用。在疾病进展中,巨噬细胞的极化、焦亡、糖代谢等功能与炎症小体,信号通路等因素联系发生改变,产生促炎因子,进而引起骨破坏及关节障碍,本文就巨噬细胞极化、焦亡、糖代谢与类风湿关节炎的关系进行综述,为类风湿关节炎的治疗提供参考。Irreversible bone damage in rheumatoid arthritis is the result of immune cell infiltration and fibroblast-like synovial cell proliferation. The main pathological features are synovitis and pannus formation. Macrophages, as human immune cells, play an important role in rheumatoid arthritis. On the one hand, the destruction of immune homeostasis directly induces systemic inflammation, and macrophages trigger and continue synovitis and tissue damage through interaction with fibroblast-like synovial cells. On the other hand, the polarization of macrophages plays a dual role of pro-inflammatory and anti-inflammatory in the development of rheumatoid arthritis. In the progression of the disease, the functions of macrophages such as polarization, pyroptosis, and glucose metabolism are changed in connection with factors such as inflammasomes and signaling pathways, resulting in pro-inflammatory factors, which in turn cause bone destruction and joint disorders. This article reviews the relationship between macrophage polarization, pyroptosis, glucose metabolism and rheumatoid arthritis, and provides a reference for the treatment of rheumatoid arthritis.展开更多
围绝经期综合征是临床常见疾病之一,自然绝经或人工绝经都可引发此病。此病症状复杂,病程长短不一,西医多通过激素补充治疗,见效快,但是禁忌证、不良反应相对较多。祖国医学中对于此病并无明确记载,现多将其归为“绝经前后诸证”的范畴...围绝经期综合征是临床常见疾病之一,自然绝经或人工绝经都可引发此病。此病症状复杂,病程长短不一,西医多通过激素补充治疗,见效快,但是禁忌证、不良反应相对较多。祖国医学中对于此病并无明确记载,现多将其归为“绝经前后诸证”的范畴。现代中医继承前人从肾论治此病的经验,发展到现在从肝肾论治此病,本文对近5年来有关中医药从肝肾论治围绝经期综合征的文献进行归纳、整理和总结,以期为今后中医药治疗在防治围绝经期综合征方面提供更多的借鉴与参考。Perimenopausal syndrome is one of the common clinical diseases, natural menopause or artificial menopause can cause this disease. The symptoms of this disease are complex, and the length of the disease is different. Western medicine mostly treats it with hormone supplement, which has a quick effect, but there are many contraindications, and adverse reactions are relatively more. There is no clear record of this disease in Chinese medicine, and it is often classified as the category of “before and after menopausal symptoms”. Modern traditional Chinese medicine predecessors inherit the experience of treating this disease from the kidney theory and develop the treatment of this disease from the liver and kidney theory. This article summarizes, organizes, and concludes the literature on the treatment of perimenopausal syndrome in traditional Chinese medicine from the liver and kidney theory in the past five years, in order to provide more reference for the future treatment of traditional Chinese medicine in the prevention and treatment of perimenopausal syndrome.展开更多
文摘类风湿关节炎骨质发生不可逆性损坏是免疫细胞浸润与成纤维样滑膜细胞增殖的结果,其主要病理特征为滑膜炎与血管翳生成。巨噬细胞作为人体免疫细胞,在类风湿性关节炎中起着重要作用。一方面,免疫稳态的破坏直接诱发全身炎症,巨噬细胞通过与成纤维细胞样滑膜细胞的相互作用引发并延续滑膜炎和组织损伤;另一方面,巨噬细胞的极化在类风湿关节炎发展过程中起着促炎及抗炎双重作用。在疾病进展中,巨噬细胞的极化、焦亡、糖代谢等功能与炎症小体,信号通路等因素联系发生改变,产生促炎因子,进而引起骨破坏及关节障碍,本文就巨噬细胞极化、焦亡、糖代谢与类风湿关节炎的关系进行综述,为类风湿关节炎的治疗提供参考。Irreversible bone damage in rheumatoid arthritis is the result of immune cell infiltration and fibroblast-like synovial cell proliferation. The main pathological features are synovitis and pannus formation. Macrophages, as human immune cells, play an important role in rheumatoid arthritis. On the one hand, the destruction of immune homeostasis directly induces systemic inflammation, and macrophages trigger and continue synovitis and tissue damage through interaction with fibroblast-like synovial cells. On the other hand, the polarization of macrophages plays a dual role of pro-inflammatory and anti-inflammatory in the development of rheumatoid arthritis. In the progression of the disease, the functions of macrophages such as polarization, pyroptosis, and glucose metabolism are changed in connection with factors such as inflammasomes and signaling pathways, resulting in pro-inflammatory factors, which in turn cause bone destruction and joint disorders. This article reviews the relationship between macrophage polarization, pyroptosis, glucose metabolism and rheumatoid arthritis, and provides a reference for the treatment of rheumatoid arthritis.
文摘围绝经期综合征是临床常见疾病之一,自然绝经或人工绝经都可引发此病。此病症状复杂,病程长短不一,西医多通过激素补充治疗,见效快,但是禁忌证、不良反应相对较多。祖国医学中对于此病并无明确记载,现多将其归为“绝经前后诸证”的范畴。现代中医继承前人从肾论治此病的经验,发展到现在从肝肾论治此病,本文对近5年来有关中医药从肝肾论治围绝经期综合征的文献进行归纳、整理和总结,以期为今后中医药治疗在防治围绝经期综合征方面提供更多的借鉴与参考。Perimenopausal syndrome is one of the common clinical diseases, natural menopause or artificial menopause can cause this disease. The symptoms of this disease are complex, and the length of the disease is different. Western medicine mostly treats it with hormone supplement, which has a quick effect, but there are many contraindications, and adverse reactions are relatively more. There is no clear record of this disease in Chinese medicine, and it is often classified as the category of “before and after menopausal symptoms”. Modern traditional Chinese medicine predecessors inherit the experience of treating this disease from the kidney theory and develop the treatment of this disease from the liver and kidney theory. This article summarizes, organizes, and concludes the literature on the treatment of perimenopausal syndrome in traditional Chinese medicine from the liver and kidney theory in the past five years, in order to provide more reference for the future treatment of traditional Chinese medicine in the prevention and treatment of perimenopausal syndrome.
