Predicting essential proteins is crucial for discovering the process of cellular organization and viability.We propose biased random walk with restart algorithm for essential proteins prediction,called BRWR.Firstly,th...Predicting essential proteins is crucial for discovering the process of cellular organization and viability.We propose biased random walk with restart algorithm for essential proteins prediction,called BRWR.Firstly,the common process of practice walk often sets the probability of particles transferring to adjacent nodes to be equal,neglecting the influence of the similarity structure on the transition probability.To address this problem,we redefine a novel transition probability matrix by integrating the gene express similarity and subcellular location similarity.The particles can obtain biased transferring probabilities to perform random walk so as to further exploit biological properties embedded in the network structure.Secondly,we use gene ontology(GO)terms score and subcellular score to calculate the initial probability vector of the random walk with restart.Finally,when the biased random walk with restart process reaches steady state,the protein importance score is obtained.In order to demonstrate superiority of BRWR,we conduct experiments on the YHQ,BioGRID,Krogan and Gavin PPI networks.The results show that the method BRWR is superior to other state-of-the-art methods in essential proteins recognition performance.Especially,compared with the contrast methods,the improvements of BRWR in terms of the ACC results range in 1.4%–5.7%,1.3%–11.9%,2.4%–8.8%,and 0.8%–14.2%,respectively.Therefore,BRWR is effective and reasonable.展开更多
目的对武汉市某强制戒毒所静脉吸毒人群进行美沙酮及艾滋病健康教育,并对健康教育的效果进行评价。方法随机抽取武汉某强制戒毒所男性静脉吸毒人员81人,随机分成两组,对干预组开展美沙酮及艾滋病健康教育。干预系列活动后对干预组和对...目的对武汉市某强制戒毒所静脉吸毒人群进行美沙酮及艾滋病健康教育,并对健康教育的效果进行评价。方法随机抽取武汉某强制戒毒所男性静脉吸毒人员81人,随机分成两组,对干预组开展美沙酮及艾滋病健康教育。干预系列活动后对干预组和对照组进行问卷调查评价干预效果。结果干预组对美沙酮维持治疗的作用、优点和治疗期间禁忌的知识知晓率高于对照组(均有P<0.05);干预组对美沙酮治疗效果评价好于对照组(P=0.002);干预组对自愿咨询检测(voluntary counseling and testing,VCT)的地点、国家防艾"四免一关怀"政策内容、生育和哺乳可能传播HIV、无保护的性行为可能感染HIV、蚊虫叮咬不会传播HIV、日常接触不会传播HIV、艾滋病传播途径等7个艾滋病知识知晓率高于对照组(均有P<0.05)。结论在强制戒毒所对静脉吸毒人员进行多种形式的美沙酮维持治疗及艾滋病健康教育,效果良好,应定期开展,成为艾滋病防治的常态工作。展开更多
文摘在J2ME规范的基础上,以移动邮件的收发规则为基础,以W eb mail服务器为后台中心,从邮件账号的设置、邮件收发、好友地址保存出发,分模块实现了整个系统。详细阐述了系统设计的思想、结构框架。系统采用Servlet技术以及JavaMail技术作为中间层,解决了邮件收发的技术问题。使用了J2ME高级界面API、XML、多线程、永久记录存储和通用联网框架GCF等多项技术实现M ID let客户端。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11861045 and 62162040)。
文摘Predicting essential proteins is crucial for discovering the process of cellular organization and viability.We propose biased random walk with restart algorithm for essential proteins prediction,called BRWR.Firstly,the common process of practice walk often sets the probability of particles transferring to adjacent nodes to be equal,neglecting the influence of the similarity structure on the transition probability.To address this problem,we redefine a novel transition probability matrix by integrating the gene express similarity and subcellular location similarity.The particles can obtain biased transferring probabilities to perform random walk so as to further exploit biological properties embedded in the network structure.Secondly,we use gene ontology(GO)terms score and subcellular score to calculate the initial probability vector of the random walk with restart.Finally,when the biased random walk with restart process reaches steady state,the protein importance score is obtained.In order to demonstrate superiority of BRWR,we conduct experiments on the YHQ,BioGRID,Krogan and Gavin PPI networks.The results show that the method BRWR is superior to other state-of-the-art methods in essential proteins recognition performance.Especially,compared with the contrast methods,the improvements of BRWR in terms of the ACC results range in 1.4%–5.7%,1.3%–11.9%,2.4%–8.8%,and 0.8%–14.2%,respectively.Therefore,BRWR is effective and reasonable.
文摘目的对武汉市某强制戒毒所静脉吸毒人群进行美沙酮及艾滋病健康教育,并对健康教育的效果进行评价。方法随机抽取武汉某强制戒毒所男性静脉吸毒人员81人,随机分成两组,对干预组开展美沙酮及艾滋病健康教育。干预系列活动后对干预组和对照组进行问卷调查评价干预效果。结果干预组对美沙酮维持治疗的作用、优点和治疗期间禁忌的知识知晓率高于对照组(均有P<0.05);干预组对美沙酮治疗效果评价好于对照组(P=0.002);干预组对自愿咨询检测(voluntary counseling and testing,VCT)的地点、国家防艾"四免一关怀"政策内容、生育和哺乳可能传播HIV、无保护的性行为可能感染HIV、蚊虫叮咬不会传播HIV、日常接触不会传播HIV、艾滋病传播途径等7个艾滋病知识知晓率高于对照组(均有P<0.05)。结论在强制戒毒所对静脉吸毒人员进行多种形式的美沙酮维持治疗及艾滋病健康教育,效果良好,应定期开展,成为艾滋病防治的常态工作。
