We study the feasibility and safety of human lung hyperpolarized（HP）^（129）Xe magnetic resonance imaging（MRI）.There is no significant change in physiological parameters before and after the examinations of all su...We study the feasibility and safety of human lung hyperpolarized（HP）^（129）Xe magnetic resonance imaging（MRI）.There is no significant change in physiological parameters before and after the examinations of all subjects.Compared with computed tomography, HP^（129）Xe MRI is sensitive to earlier and smaller ventilation defects. The distribution of the HP^（129）Xe MRI signal reflects the pulmonary compliance with the gravity gradient. This is the first application of HP^（129）Xe MRI ventilation imaging in China, and this technology is expected to provide more useful information for clinical practice.展开更多
基金supported by the Program of Clinical Research Center for Medical Imaging in Hunan Province(2020SK4001)the New Medical technology of the Second Xiangya Hospital of Central South University([2019]04 and[2021]175)the Extracurricular Scientific Research Training Program for Medical Students of Central South University(202029KT519),China。
文摘目的:随着肺结节检出率的不断提高,肺结节的定性问题已成为临床重点关注问题之一。本研究旨在探讨T1加权自由呼吸容积内插3D扰相梯度回波序列(T1-weighted free-breathing star-volumetric interpolated breath-hold examination,T_(1)WI star-VIBE)结合时间分辨交叉随机轨迹成像的容积内插3D扰相梯度回波序列(time-resolved imaging with interleaved stochastic trajectories-volume interpolated breath hold examination,TWIST-VIBE)动态增强MRI对良恶性肺结节的鉴别价值。方法:回顾性纳入79例术前未定性肺结节且年龄大于18岁的患者,所有结节被分为恶性结节(n=58)和良性结节(n=26)。分别对结节的T1加权容积内插3D扰相梯度回波序列(T1WI-volumetric interpolated breath hold examination,T1WI-VIBE)平扫信号强度、T1WI-VIBE增强特征以及基于TWIST-VIBE的动态对比增强曲线进行分析,评估相应的定性(流入时间、流出时间、达峰时间、到达时间、正性积分)和定量参数(容积转移常数、速率转移常数、血管外细胞外间隙容积比),同时比较增强CT与MRI的诊断效能(灵敏度和特异度)。结果:肺部良、恶性结节的T1WI-VIBE平扫低信号,A、B、C型DCE曲线类型均存在统计学差异(均P<0.001),肺部恶性结节流出时间短于良性结节(P=0.001),其余参数差异均无统计学意义(均P>0.05)。同时,经过T_(1)WI star-VIBE增强MR扫描后,图像质量有进一步提高。与增强CT扫描相比,基于MRI的诊断灵敏度(82.76%vs 80.50%)及特异度(69.23%vs57.10%)均高于CT(均P<0.001)。结论:T_(1)WI star-VIBE和基于TWIST-VIBE的动态增强MRI可以在提高图像清晰度的同时为临床鉴别肺结节良恶性提供更多的信息。
基金Supported by the National Natural Science Foundation of China under Grant Nos 81227902 and 81625011the National Key Research and Development Program of China under Grant No 2016YFC1304702the Key Research Program of Frontier Sciences of CAS(QYZDY-SSW-SLH018)
文摘We study the feasibility and safety of human lung hyperpolarized（HP）^（129）Xe magnetic resonance imaging（MRI）.There is no significant change in physiological parameters before and after the examinations of all subjects.Compared with computed tomography, HP^（129）Xe MRI is sensitive to earlier and smaller ventilation defects. The distribution of the HP^（129）Xe MRI signal reflects the pulmonary compliance with the gravity gradient. This is the first application of HP^（129）Xe MRI ventilation imaging in China, and this technology is expected to provide more useful information for clinical practice.
