失眠是一种常见的临床疾病,表现为入睡困难,早醒,睡眠时间短甚至彻夜不眠,严重影响患者生活质量。临床上常将其分为原发性失眠和继发性失眠两大类。近年来,失眠的机制已被证实与脑神经有关,但其潜在的内分泌机制尚不清楚。本文基于目前...失眠是一种常见的临床疾病,表现为入睡困难,早醒,睡眠时间短甚至彻夜不眠,严重影响患者生活质量。临床上常将其分为原发性失眠和继发性失眠两大类。近年来,失眠的机制已被证实与脑神经有关,但其潜在的内分泌机制尚不清楚。本文基于目前国内外失眠的神经–内分泌–免疫机制的前沿进展,从调节神经递质、调节内分泌激素、调节免疫细胞因子等方面入手,对失眠的内分泌机制进行论述,归纳治疗失眠的中医常见临床方法与内分泌机制的潜在联系,总结中医治疗失眠的独特优势。Insomnia is a common clinical disease, manifested as difficulty in falling asleep, early awakening, short sleep time or even sleepless nights, which seriously affects the quality of life of patients. Clinically, it is often categorized into two main types: primary insomnia and secondary insomnia. In recent years, the mechanism of insomnia has been proved to be related to the brain nerves, but its underlying endocrine mechanism is still unclear. Based on the frontier progress of the neuro-endocrine-immune mechanism of insomnia at home and abroad, this paper discusses the endocrine mechanism of insomnia from the aspects of regulating neurotransmitters, regulating endocrine hormones and regulating immune cytokines, summarizes the potential connection between common clinical methods of Chinese medicine for treating insomnia and the endocrine mechanism, and concludes the unique advantages of Chinese medicine in treating insomnia.展开更多
文摘失眠是一种常见的临床疾病,表现为入睡困难,早醒,睡眠时间短甚至彻夜不眠,严重影响患者生活质量。临床上常将其分为原发性失眠和继发性失眠两大类。近年来,失眠的机制已被证实与脑神经有关,但其潜在的内分泌机制尚不清楚。本文基于目前国内外失眠的神经–内分泌–免疫机制的前沿进展,从调节神经递质、调节内分泌激素、调节免疫细胞因子等方面入手,对失眠的内分泌机制进行论述,归纳治疗失眠的中医常见临床方法与内分泌机制的潜在联系,总结中医治疗失眠的独特优势。Insomnia is a common clinical disease, manifested as difficulty in falling asleep, early awakening, short sleep time or even sleepless nights, which seriously affects the quality of life of patients. Clinically, it is often categorized into two main types: primary insomnia and secondary insomnia. In recent years, the mechanism of insomnia has been proved to be related to the brain nerves, but its underlying endocrine mechanism is still unclear. Based on the frontier progress of the neuro-endocrine-immune mechanism of insomnia at home and abroad, this paper discusses the endocrine mechanism of insomnia from the aspects of regulating neurotransmitters, regulating endocrine hormones and regulating immune cytokines, summarizes the potential connection between common clinical methods of Chinese medicine for treating insomnia and the endocrine mechanism, and concludes the unique advantages of Chinese medicine in treating insomnia.
