目的探讨不同程度小于胎龄儿(small for gestational age,SGA)发生的影响因素,为早期识别重度SGA的发生提供依据。方法回顾性收集2018年1月—2022年12月北京大学人民医院产科出生的新生儿及其母亲围产期资料。新生儿分为重度SGA组(出生...目的探讨不同程度小于胎龄儿(small for gestational age,SGA)发生的影响因素,为早期识别重度SGA的发生提供依据。方法回顾性收集2018年1月—2022年12月北京大学人民医院产科出生的新生儿及其母亲围产期资料。新生儿分为重度SGA组(出生体重低于同胎龄同性别婴儿的第3百分位数)、轻度SGA组(出生体重≥第3百分位数且<第10百分位数)和非SGA组(出生体重≥第10百分位数)。采用有序多分类logistic回归模型分析不同程度SGA发生的影响因素。结果共纳入14821例新生儿,其中重度SGA组258例(1.74%),轻度SGA组902例(6.09%),非SGA组13661例(92.17%)。早产儿比例和死产比例均为重度SGA组>轻度SGA组>非SGA组(P<0.0125);重度SGA组与轻度SGA组新生儿窒息比例均大于非SGA组(P<0.0125)。有序多分类logistic回归分析显示:母孕前消瘦(OR=1.838)、母孕前肥胖(OR=3.024)、体外受精-胚胎移植(OR=2.649)、妊娠合并子痫前期(OR=1.743)、妊娠合并结缔组织病(OR=1.795)、脐带绕颈(OR=1.213)、羊水少(OR=1.848)、宫内生长受限(OR=27.691)等均与发生更严重的SGA有关(P<0.05);孕母为经产妇(OR=0.457)更倾向于不发生严重的SGA(P<0.05)。结论母孕前消瘦、母孕前肥胖、体外受精-胚胎移植、妊娠合并子痫前期、妊娠合并结缔组织病、羊水少、脐带绕颈、宫内生长受限与更严重的SGA发生密切相关;孕母为经产妇是发生严重SGA的保护因素。展开更多
The purpose of this study was to assess the differences in clinical and sonographic features of papillary thyroid carcinoma（PTC） between cervical lymph node metastatic（CLNM） and nonmetastatic groups.Clinical data ...The purpose of this study was to assess the differences in clinical and sonographic features of papillary thyroid carcinoma（PTC） between cervical lymph node metastatic（CLNM） and nonmetastatic groups.Clinical data of PTC patients（414 patients with 624 malignant nodules） who underwent a preoperative ultrasonography and surgery between June 2010 and March 2015 at Renmin Hospital of Wuhan University were retrospectively analyzed.Clinical factors,preoperative ultrasound features and the final pathological findings were obtained.The differences in the sonographic features of PTC between the CLNM group and the non-CLNM group were analyzed.There were 187 CLNM and 227 non-CLNM patients.The median age at the diagnosis of this cohort was 45.4 years old（ranging from 18 to 77 years）.Ultrasonographic parameters that were significantly associated with CLNM [OR=2.569（1.502,4.393）,P〈0.001）] were as follows：the mulifocality of the nodules,size over 2 cm,the presence of microcalcifications,the distance ratio（DR） pattern showing the contact of the nodules with the thyroid capsule,and the extracapsular spread of the nodules.No significant differences in age,gender,thyroid stimulating hormone（TSH） levels and other ultrasonography parameters were found between the CLNM and the non-CLNM groups.Therefore,our results suggest that a larger size,microcalcifications,mulifocality,and the DR pattern showing the contact of the nodules with the thyroid capsule and extracapsular spread are significantly more indicative of CLNM in PTC.展开更多
小于胎龄儿(small for gestational age,SGA)不仅是各种围产期疾病发生和围产期死亡的高危人群,也易合并多种远期代谢性疾病、心血管疾病,同时该类人群生长发育迟缓、神经发育障碍的风险也明显增加,严重影响儿童远期生存质量。本文关注...小于胎龄儿(small for gestational age,SGA)不仅是各种围产期疾病发生和围产期死亡的高危人群,也易合并多种远期代谢性疾病、心血管疾病,同时该类人群生长发育迟缓、神经发育障碍的风险也明显增加,严重影响儿童远期生存质量。本文关注SGA远期神经发育结局,从智力发育、运动发育、语言发育、感知觉发育、精神疾病等进行分类总结归纳,同时评估其神经发育障碍发生的危险因素,为促进SGA神经发育结局的改善提供参考。展开更多
目的观察外源性趋化因子5（CCL5）对人乳腺癌MCF-7细胞增殖及CD44＋／CD24-亚群比例的影响，探讨其在乳腺癌进展过程中的作用。方法噻唑蓝（MTT）比色法检测浓度为10、50、100、500μg／L的外源性rhCCL5（recombinant human CCL5）作用0...目的观察外源性趋化因子5（CCL5）对人乳腺癌MCF-7细胞增殖及CD44＋／CD24-亚群比例的影响，探讨其在乳腺癌进展过程中的作用。方法噻唑蓝（MTT）比色法检测浓度为10、50、100、500μg／L的外源性rhCCL5（recombinant human CCL5）作用0、24、48h后MCF-7细胞增殖水平的变化，流式细胞仪检测CD44＋／CD24-亚群比例的变化。结果rhCCL5作用48h后MCF-7细胞增殖水平高于对照组（P〈0．05），并呈浓度依赖趋势；且高于作用24、0h后细胞的增殖水平（P〈0．05）。50、500μg／LrhCCL5处理MCF-7细胞后升高了细胞株中CD44＋／CD24-亚群的比例，分别为对照组的5．68和6．05倍（P〈0．05）。结论外源性CCL5可以明显升高MCF-7细胞的增殖水平以及CD44＋／CD24-亚群的比例，这种作用可能是其诱导乳腺癌进展的机制之一。展开更多
文摘目的探讨不同程度小于胎龄儿(small for gestational age,SGA)发生的影响因素,为早期识别重度SGA的发生提供依据。方法回顾性收集2018年1月—2022年12月北京大学人民医院产科出生的新生儿及其母亲围产期资料。新生儿分为重度SGA组(出生体重低于同胎龄同性别婴儿的第3百分位数)、轻度SGA组(出生体重≥第3百分位数且<第10百分位数)和非SGA组(出生体重≥第10百分位数)。采用有序多分类logistic回归模型分析不同程度SGA发生的影响因素。结果共纳入14821例新生儿,其中重度SGA组258例(1.74%),轻度SGA组902例(6.09%),非SGA组13661例(92.17%)。早产儿比例和死产比例均为重度SGA组>轻度SGA组>非SGA组(P<0.0125);重度SGA组与轻度SGA组新生儿窒息比例均大于非SGA组(P<0.0125)。有序多分类logistic回归分析显示:母孕前消瘦(OR=1.838)、母孕前肥胖(OR=3.024)、体外受精-胚胎移植(OR=2.649)、妊娠合并子痫前期(OR=1.743)、妊娠合并结缔组织病(OR=1.795)、脐带绕颈(OR=1.213)、羊水少(OR=1.848)、宫内生长受限(OR=27.691)等均与发生更严重的SGA有关(P<0.05);孕母为经产妇(OR=0.457)更倾向于不发生严重的SGA(P<0.05)。结论母孕前消瘦、母孕前肥胖、体外受精-胚胎移植、妊娠合并子痫前期、妊娠合并结缔组织病、羊水少、脐带绕颈、宫内生长受限与更严重的SGA发生密切相关;孕母为经产妇是发生严重SGA的保护因素。
基金supported by the National Natural Science Foundation of China(No.81471781,No.81502665 and No.81302314/H1622)the Fundamental Research Funds of Health and Family Planning Commission of Hubei Province(No.JS-20110118)the Fundamental Research Funds for the Central Universities of China(No.2042014kf0189)
文摘The purpose of this study was to assess the differences in clinical and sonographic features of papillary thyroid carcinoma（PTC） between cervical lymph node metastatic（CLNM） and nonmetastatic groups.Clinical data of PTC patients（414 patients with 624 malignant nodules） who underwent a preoperative ultrasonography and surgery between June 2010 and March 2015 at Renmin Hospital of Wuhan University were retrospectively analyzed.Clinical factors,preoperative ultrasound features and the final pathological findings were obtained.The differences in the sonographic features of PTC between the CLNM group and the non-CLNM group were analyzed.There were 187 CLNM and 227 non-CLNM patients.The median age at the diagnosis of this cohort was 45.4 years old（ranging from 18 to 77 years）.Ultrasonographic parameters that were significantly associated with CLNM [OR=2.569（1.502,4.393）,P〈0.001）] were as follows：the mulifocality of the nodules,size over 2 cm,the presence of microcalcifications,the distance ratio（DR） pattern showing the contact of the nodules with the thyroid capsule,and the extracapsular spread of the nodules.No significant differences in age,gender,thyroid stimulating hormone（TSH） levels and other ultrasonography parameters were found between the CLNM and the non-CLNM groups.Therefore,our results suggest that a larger size,microcalcifications,mulifocality,and the DR pattern showing the contact of the nodules with the thyroid capsule and extracapsular spread are significantly more indicative of CLNM in PTC.
文摘小于胎龄儿(small for gestational age,SGA)不仅是各种围产期疾病发生和围产期死亡的高危人群,也易合并多种远期代谢性疾病、心血管疾病,同时该类人群生长发育迟缓、神经发育障碍的风险也明显增加,严重影响儿童远期生存质量。本文关注SGA远期神经发育结局,从智力发育、运动发育、语言发育、感知觉发育、精神疾病等进行分类总结归纳,同时评估其神经发育障碍发生的危险因素,为促进SGA神经发育结局的改善提供参考。
文摘目的观察外源性趋化因子5（CCL5）对人乳腺癌MCF-7细胞增殖及CD44＋／CD24-亚群比例的影响，探讨其在乳腺癌进展过程中的作用。方法噻唑蓝（MTT）比色法检测浓度为10、50、100、500μg／L的外源性rhCCL5（recombinant human CCL5）作用0、24、48h后MCF-7细胞增殖水平的变化，流式细胞仪检测CD44＋／CD24-亚群比例的变化。结果rhCCL5作用48h后MCF-7细胞增殖水平高于对照组（P〈0．05），并呈浓度依赖趋势；且高于作用24、0h后细胞的增殖水平（P〈0．05）。50、500μg／LrhCCL5处理MCF-7细胞后升高了细胞株中CD44＋／CD24-亚群的比例，分别为对照组的5．68和6．05倍（P〈0．05）。结论外源性CCL5可以明显升高MCF-7细胞的增殖水平以及CD44＋／CD24-亚群的比例，这种作用可能是其诱导乳腺癌进展的机制之一。
