简要介绍了基于飞行时间(Time of Flight,简称TOF)技术的正电子发射断层扫描成像(Posi-tron Emission Tomography,简称PET)的基本原理,回顾了TOF-PET成像设备的发展历史,讨论了影响TOF-PET时间分辨率的主要因素,并对TOF-PET给图像重建...简要介绍了基于飞行时间(Time of Flight,简称TOF)技术的正电子发射断层扫描成像(Posi-tron Emission Tomography,简称PET)的基本原理,回顾了TOF-PET成像设备的发展历史,讨论了影响TOF-PET时间分辨率的主要因素,并对TOF-PET给图像重建技术带来的挑战进行了分析。最后,重点介绍了TOF-PET技术所带来的优势,使用TOF技术可以有效地改善图像质量,并且为临床诊断和临床前研究带来便利。展开更多
Geometric calibration is critical to the accurate SPECT reconstruction. In this paper, a geometric calibration method was developed for a dedicated breast SPECT system with a tilted parallel beam （TPB） orbit. The ac...Geometric calibration is critical to the accurate SPECT reconstruction. In this paper, a geometric calibration method was developed for a dedicated breast SPECT system with a tilted parallel beam （TPB） orbit. The acquisition geometry of the breast SPECT was firstly characterized. And then its projection model was established based on the acquisition geometry. Finally, the calibration results were obtained using a nonlinear optimization method that fitted the measured projections to the model. Monte Carlo data of the breast SPECT were used to verify the calibration method. Simulation results showed that the geometric parameters with reasonable accuracy could be obtained by the proposed method.展开更多
Accurate attenuation correction is required in dedicated breast PET imaging systems for image artifact removal and quantitative studies. In this study, a method using only emission data based on consistency conditions...Accurate attenuation correction is required in dedicated breast PET imaging systems for image artifact removal and quantitative studies. In this study, a method using only emission data based on consistency conditions is proposed for attenuation correction in breast PET imaging systems. The consistency conditions are exploited to evaluate the accuracy of the estimated attenuation distribution and find the appropriate parameters that yield the most consistent attenuation distribution with the measured emission data. We have proved the validity of the method with experimental investigations and single-patient studies using a dedicated breast PET. The results show that the method is capable of accurately estimating the attenuation distribution of a uniform attenuator from the experimental data with various relatively low activities. The results also show that in single-patient studies, the method is robust for the irregular boundary of breast tissue and provides a distinct improvement in image quality.展开更多
文摘简要介绍了基于飞行时间(Time of Flight,简称TOF)技术的正电子发射断层扫描成像(Posi-tron Emission Tomography,简称PET)的基本原理,回顾了TOF-PET成像设备的发展历史,讨论了影响TOF-PET时间分辨率的主要因素,并对TOF-PET给图像重建技术带来的挑战进行了分析。最后,重点介绍了TOF-PET技术所带来的优势,使用TOF技术可以有效地改善图像质量,并且为临床诊断和临床前研究带来便利。
基金Supported by National Natural Science Foundation of China (118110117465)
文摘Geometric calibration is critical to the accurate SPECT reconstruction. In this paper, a geometric calibration method was developed for a dedicated breast SPECT system with a tilted parallel beam （TPB） orbit. The acquisition geometry of the breast SPECT was firstly characterized. And then its projection model was established based on the acquisition geometry. Finally, the calibration results were obtained using a nonlinear optimization method that fitted the measured projections to the model. Monte Carlo data of the breast SPECT were used to verify the calibration method. Simulation results showed that the geometric parameters with reasonable accuracy could be obtained by the proposed method.
基金Supported by National Natural Science Foundation of China(81101070)
文摘Accurate attenuation correction is required in dedicated breast PET imaging systems for image artifact removal and quantitative studies. In this study, a method using only emission data based on consistency conditions is proposed for attenuation correction in breast PET imaging systems. The consistency conditions are exploited to evaluate the accuracy of the estimated attenuation distribution and find the appropriate parameters that yield the most consistent attenuation distribution with the measured emission data. We have proved the validity of the method with experimental investigations and single-patient studies using a dedicated breast PET. The results show that the method is capable of accurately estimating the attenuation distribution of a uniform attenuator from the experimental data with various relatively low activities. The results also show that in single-patient studies, the method is robust for the irregular boundary of breast tissue and provides a distinct improvement in image quality.
