基金supported by the National Natural Science Foundation of China(No.81672548,81874098 and 82072845 to C.C.W.,No.81572536 and 81902609 to S.Y.)Program for Professor of Special Appointment(Eastern Scholar)+5 种基金Shanghai Institutions of Higher Learning(No.2016012 to C.C.W.)State Key Laboratory of Oncogenes and Related Genes(No.97-17-01 to C.C.W.)Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(C.C.W.)Shanghai Municipal Science and Technology Commission(No.19410740400 to C.C.W.,20WZ2504600 to M.C.W.)Shanghai Jiao Tong University School of Medicine Postdoctoral Incentive Program(S.Y.)111 Project(No.B21024)。