目的观察金龙胶囊联合化疗对胃癌患者生活质量和免疫功能的影响。方法采用随机双盲阳性对照研究,将42例经病理组织学确诊的胃癌患者随机分为治疗组(21例)和对照组(21例),采用FOXFOL4或PF方案化疗2个周期。在化疗基础上,治疗组服用金龙胶...目的观察金龙胶囊联合化疗对胃癌患者生活质量和免疫功能的影响。方法采用随机双盲阳性对照研究,将42例经病理组织学确诊的胃癌患者随机分为治疗组(21例)和对照组(21例),采用FOXFOL4或PF方案化疗2个周期。在化疗基础上,治疗组服用金龙胶囊4粒/次,每日3次;对照组口服贞芪扶正胶囊4粒/次,每日3次。所有患者均持续服药42 d。观察两组治疗前后Karnofsky评分、体质量变化及T淋巴细胞亚群和自然杀伤细胞(natural killer,NK)数量的变化。结果治疗组治疗后Karnofsky评分,白细胞分化抗原3阳性(cluster of differentiation 3 positive,CD3+)、白细胞分化抗原4阳性(cluster of differentia-tion 4 positive,CD4+)、白细胞分化抗原8阳性(cluster of differentiation 8 positive,CD8+)T淋巴细胞和NK细胞数量较治疗前均有提高,但差异无统计学意义(P>0.05);对照组治疗后Karnofsky评分较治疗前明显提高(P<0.01)。治疗后治疗组患者体质量、CD4+T细胞和NK细胞数量较对照组提高,差异无统计学意义(P>0.05)。结论金龙胶囊和贞芪扶正胶囊有等效作用,能提高胃癌患者的免疫功能,有助于改善患者生活质量。展开更多
Computer aided drug design is to develop a chemical that binds to a target macromolecule known to play a key role in a disease state. In recognition of ligands by their protein receptors, molecular surfaces are often...Computer aided drug design is to develop a chemical that binds to a target macromolecule known to play a key role in a disease state. In recognition of ligands by their protein receptors, molecular surfaces are often used because they represent the interacting part of molecules and they should reflex the complementarity between ligand and receptor. However, assessing the surface complementarity by searching all relative position of two surfaces is often computationally expensive. The complementarity of lobe hole is very important in protein ligand interactions. Spherical harmonic models based on expansions of spherical harmonic functions were used as a fingerprint to approximate the binding cavity and the ligand, respectively. This defines a new way to identify the complementarity between lobes and holes. The advantage of this method is that two spherical harmonic surfaces to be compared can be defined separately. This method can be used as a filter to eliminate candidates among a large number of conformations, and it will speed up the docking procedure. Therefore, it is possible to select complementary ligands or complementary conformations of a ligand and the macromolecules, by comparing their fingerprints previously stored in a database.展开更多
文摘目的观察金龙胶囊联合化疗对胃癌患者生活质量和免疫功能的影响。方法采用随机双盲阳性对照研究,将42例经病理组织学确诊的胃癌患者随机分为治疗组(21例)和对照组(21例),采用FOXFOL4或PF方案化疗2个周期。在化疗基础上,治疗组服用金龙胶囊4粒/次,每日3次;对照组口服贞芪扶正胶囊4粒/次,每日3次。所有患者均持续服药42 d。观察两组治疗前后Karnofsky评分、体质量变化及T淋巴细胞亚群和自然杀伤细胞(natural killer,NK)数量的变化。结果治疗组治疗后Karnofsky评分,白细胞分化抗原3阳性(cluster of differentiation 3 positive,CD3+)、白细胞分化抗原4阳性(cluster of differentia-tion 4 positive,CD4+)、白细胞分化抗原8阳性(cluster of differentiation 8 positive,CD8+)T淋巴细胞和NK细胞数量较治疗前均有提高,但差异无统计学意义(P>0.05);对照组治疗后Karnofsky评分较治疗前明显提高(P<0.01)。治疗后治疗组患者体质量、CD4+T细胞和NK细胞数量较对照组提高,差异无统计学意义(P>0.05)。结论金龙胶囊和贞芪扶正胶囊有等效作用,能提高胃癌患者的免疫功能,有助于改善患者生活质量。
文摘Computer aided drug design is to develop a chemical that binds to a target macromolecule known to play a key role in a disease state. In recognition of ligands by their protein receptors, molecular surfaces are often used because they represent the interacting part of molecules and they should reflex the complementarity between ligand and receptor. However, assessing the surface complementarity by searching all relative position of two surfaces is often computationally expensive. The complementarity of lobe hole is very important in protein ligand interactions. Spherical harmonic models based on expansions of spherical harmonic functions were used as a fingerprint to approximate the binding cavity and the ligand, respectively. This defines a new way to identify the complementarity between lobes and holes. The advantage of this method is that two spherical harmonic surfaces to be compared can be defined separately. This method can be used as a filter to eliminate candidates among a large number of conformations, and it will speed up the docking procedure. Therefore, it is possible to select complementary ligands or complementary conformations of a ligand and the macromolecules, by comparing their fingerprints previously stored in a database.
