The human brain is highly plastic.Cognitive training is usually used to modify functional connectivity of brain networks.Moreover,the structures of brain networks may determine its dynamic behavior which is related to...The human brain is highly plastic.Cognitive training is usually used to modify functional connectivity of brain networks.Moreover,the structures of brain networks may determine its dynamic behavior which is related to human cognitive abilities.To study the effect of functional connectivity on the brain dynamics,the dynamic model based on functional connections of the brain and the Hindmarsh–Rose model is utilized in this work.The resting-state fMRI data from the experimental group undergoing abacus-based mental calculation(AMC)training and from the control group are used to construct the functional brain networks.The dynamic behavior of brain at the resting and task states for the AMC group and the control group are simulated with the above-mentioned dynamic model.In the resting state,there are the differences of brain activation between the AMC group and the control group,and more brain regions are inspired in the AMC group.A stimulus with sinusoidal signals to brain networks is introduced to simulate the brain dynamics in the task states.The dynamic characteristics are extracted by the excitation rates,the response intensities and the state distributions.The change in the functional connectivity of brain networks with the AMC training would in turn improve the brain response to external stimulus,and make the brain more efficient in processing tasks.展开更多
目的探讨三七皂苷Rg1对慢性应激模型大鼠皮层、海马神经颗粒素(neurogranin,Ng)表达的影响.方法成年雄性SD大鼠36只,随机分为对照组(CON)、模型组(CUS)和治疗组(CUS-G),采用慢性不可预见性应激方法建立慢性应激动物模型,运用Morris水迷...目的探讨三七皂苷Rg1对慢性应激模型大鼠皮层、海马神经颗粒素(neurogranin,Ng)表达的影响.方法成年雄性SD大鼠36只,随机分为对照组(CON)、模型组(CUS)和治疗组(CUS-G),采用慢性不可预见性应激方法建立慢性应激动物模型,运用Morris水迷宫实验对大鼠进行学习记忆力测试,QPCR、Western blot分别检测皮层、海马Ng m RNA及Ng蛋白含量.结果水迷宫实验显示慢性应激后动物学习记忆能力显著降低,而治疗组大鼠逃避潜伏期明显降低(P<0.0 5);应激6周后,慢性应激大鼠皮层、海马Ng m RNA水平皆与模型大鼠有差异(P<0.05、P<0.01),治疗组大鼠皮层、海马Ng m RNA水平皆与模型大鼠有差异(P<0.01、P<0.05);慢性应激大鼠皮层、海马Ng含量水平与模型大鼠有差异(P<0.05、P<0.01),治疗大鼠皮层、海马Ng含量亦与模型大鼠有差异(P<0.01、P<0.05).结论慢性不可预见性应激导致大鼠皮层、海马Ng m RNA水平、NG蛋白含量显著下降,造成大鼠学习记忆功能减退,三七皂苷Rg1可上调Ng m RNA水平、NG蛋白含量表达,且对慢性应激所致外显行为有积极调节作用.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62276229 and 32071096).
文摘The human brain is highly plastic.Cognitive training is usually used to modify functional connectivity of brain networks.Moreover,the structures of brain networks may determine its dynamic behavior which is related to human cognitive abilities.To study the effect of functional connectivity on the brain dynamics,the dynamic model based on functional connections of the brain and the Hindmarsh–Rose model is utilized in this work.The resting-state fMRI data from the experimental group undergoing abacus-based mental calculation(AMC)training and from the control group are used to construct the functional brain networks.The dynamic behavior of brain at the resting and task states for the AMC group and the control group are simulated with the above-mentioned dynamic model.In the resting state,there are the differences of brain activation between the AMC group and the control group,and more brain regions are inspired in the AMC group.A stimulus with sinusoidal signals to brain networks is introduced to simulate the brain dynamics in the task states.The dynamic characteristics are extracted by the excitation rates,the response intensities and the state distributions.The change in the functional connectivity of brain networks with the AMC training would in turn improve the brain response to external stimulus,and make the brain more efficient in processing tasks.
文摘目的探讨三七皂苷Rg1对慢性应激模型大鼠皮层、海马神经颗粒素(neurogranin,Ng)表达的影响.方法成年雄性SD大鼠36只,随机分为对照组(CON)、模型组(CUS)和治疗组(CUS-G),采用慢性不可预见性应激方法建立慢性应激动物模型,运用Morris水迷宫实验对大鼠进行学习记忆力测试,QPCR、Western blot分别检测皮层、海马Ng m RNA及Ng蛋白含量.结果水迷宫实验显示慢性应激后动物学习记忆能力显著降低,而治疗组大鼠逃避潜伏期明显降低(P<0.0 5);应激6周后,慢性应激大鼠皮层、海马Ng m RNA水平皆与模型大鼠有差异(P<0.05、P<0.01),治疗组大鼠皮层、海马Ng m RNA水平皆与模型大鼠有差异(P<0.01、P<0.05);慢性应激大鼠皮层、海马Ng含量水平与模型大鼠有差异(P<0.05、P<0.01),治疗大鼠皮层、海马Ng含量亦与模型大鼠有差异(P<0.01、P<0.05).结论慢性不可预见性应激导致大鼠皮层、海马Ng m RNA水平、NG蛋白含量显著下降,造成大鼠学习记忆功能减退,三七皂苷Rg1可上调Ng m RNA水平、NG蛋白含量表达,且对慢性应激所致外显行为有积极调节作用.
