Phosphodiesterase Ⅴ inhibitor Sildenafil was synthesized by a new synthetic route.The hydrazine hydrate was used as deoxidizer in synthesizing of intermediate 4 amino 1 methyl 3 n propylpyrazole 5 carboxamide,the yie...Phosphodiesterase Ⅴ inhibitor Sildenafil was synthesized by a new synthetic route.The hydrazine hydrate was used as deoxidizer in synthesizing of intermediate 4 amino 1 methyl 3 n propylpyrazole 5 carboxamide,the yield being 91 5%.Surfactants was used in the process of the cycliztion.The yield was 8% higher than the original technology.This route is unique in that only common reagents are required.rection conditions are mild,and the process is simple,being with out use of silicon colum chromatography treatment.It is therefore suitable for industrial production.展开更多
文摘Phosphodiesterase Ⅴ inhibitor Sildenafil was synthesized by a new synthetic route.The hydrazine hydrate was used as deoxidizer in synthesizing of intermediate 4 amino 1 methyl 3 n propylpyrazole 5 carboxamide,the yield being 91 5%.Surfactants was used in the process of the cycliztion.The yield was 8% higher than the original technology.This route is unique in that only common reagents are required.rection conditions are mild,and the process is simple,being with out use of silicon colum chromatography treatment.It is therefore suitable for industrial production.
