The paper reports the formation and crystal structure of dihydronitidine, expounds thereasons and conditions of easily formed oxynitidine, and discusses anticancer mechanism ofnitidine (cation). The crystallographic p...The paper reports the formation and crystal structure of dihydronitidine, expounds thereasons and conditions of easily formed oxynitidine, and discusses anticancer mechanism ofnitidine (cation). The crystallographic parameters of dihydronitidine are: space group P2_(1/n),a= 12.54(1), b = 9. 148(5), c = 14.748(8)A, β= 92. 12(6)°,Z =4. 4108 independent reflec-tions were collected within the range of 3°≤2θ≤54°, of which 2137 intensity data with I≥3σ(I) were used in the structural determination. The crystal structure has been refined byfull matrix least-square method to a final R of 0.050.展开更多
Nitidine chloride and oxynitidine were isolated from zanthoxylum nitidum by HUANG Zhi-xun et al. in 1980. Nitidine chloride exhibits good antitumor activity but oxynitidine does not. Recently we carried out a reaction...Nitidine chloride and oxynitidine were isolated from zanthoxylum nitidum by HUANG Zhi-xun et al. in 1980. Nitidine chloride exhibits good antitumor activity but oxynitidine does not. Recently we carried out a reaction in which the mixture of some nitidine chloride powder and NaOH aqueous solution was exposed to air and heated展开更多
I.INTRODUCTION The compound C24H30O9,named macrocalin-A, was isolated by Cheng Peiyuan et al. from Rabdosia macrocalyx （Dunn） Hava, a Chinese anticancer herb. Its structural formula was inferred by means of spectros...I.INTRODUCTION The compound C24H30O9,named macrocalin-A, was isolated by Cheng Peiyuan et al. from Rabdosia macrocalyx （Dunn） Hava, a Chinese anticancer herb. Its structural formula was inferred by means of spectroscopic analysis as follows:展开更多
Ⅰ. INTRODUCTIONIn order to search for new antiearcinoma drugs, Zhang Guo-min et al. synthesized a series of diarylboric α-aminoacid derivatives. These derivatives show good antiearcinoma activities in in vitro studi...Ⅰ. INTRODUCTIONIn order to search for new antiearcinoma drugs, Zhang Guo-min et al. synthesized a series of diarylboric α-aminoacid derivatives. These derivatives show good antiearcinoma activities in in vitro studies. Wu Zi-wu et al. reported the single crystal structure of bis (m-展开更多
I. INTRODUCTIONTwo sesquiterpene alkaloids were isolated from the root skin of Tripterygium Wilfordii Hook. f. by Deng Fu-xiao et al., and named euonine (Ⅰ) and wilfomine (Ⅱ), respectively. They show immunosuppressi...I. INTRODUCTIONTwo sesquiterpene alkaloids were isolated from the root skin of Tripterygium Wilfordii Hook. f. by Deng Fu-xiao et al., and named euonine (Ⅰ) and wilfomine (Ⅱ), respectively. They show immunosuppressives after their pharmacological activities were studied by Zheng You-lan et al. The other alkaloids, from Tripterygium Wilfordii Hook.展开更多
Ⅰ. INTRODUCTION Seven alkaloids were isolated from the roots of Zanthoxylum nitidum by HUANG Zhi-xun et al. The compound C<sub>22</sub>H<sub>21</sub>O<sub>5</sub>N, named 6-methoxy...Ⅰ. INTRODUCTION Seven alkaloids were isolated from the roots of Zanthoxylum nitidum by HUANG Zhi-xun et al. The compound C<sub>22</sub>H<sub>21</sub>O<sub>5</sub>N, named 6-methoxy-5, 6-dihydrochelerythrine, was one of the alkaloids. It exhibits medium antitumor activity.We carry out the X-ray structural analysis of the drug in order to study the relation between the molecular structure and its antitumor activities.展开更多
基金Project supported by the Natural Science Foundation of Fujian Province.
文摘The paper reports the formation and crystal structure of dihydronitidine, expounds thereasons and conditions of easily formed oxynitidine, and discusses anticancer mechanism ofnitidine (cation). The crystallographic parameters of dihydronitidine are: space group P2_(1/n),a= 12.54(1), b = 9. 148(5), c = 14.748(8)A, β= 92. 12(6)°,Z =4. 4108 independent reflec-tions were collected within the range of 3°≤2θ≤54°, of which 2137 intensity data with I≥3σ(I) were used in the structural determination. The crystal structure has been refined byfull matrix least-square method to a final R of 0.050.
基金Project supported by the Science Foundation of Fujian Province
文摘Nitidine chloride and oxynitidine were isolated from zanthoxylum nitidum by HUANG Zhi-xun et al. in 1980. Nitidine chloride exhibits good antitumor activity but oxynitidine does not. Recently we carried out a reaction in which the mixture of some nitidine chloride powder and NaOH aqueous solution was exposed to air and heated
文摘I.INTRODUCTION The compound C24H30O9,named macrocalin-A, was isolated by Cheng Peiyuan et al. from Rabdosia macrocalyx （Dunn） Hava, a Chinese anticancer herb. Its structural formula was inferred by means of spectroscopic analysis as follows:
基金Project supported by the Science Foundation of Fujian Province.
文摘Ⅰ. INTRODUCTIONIn order to search for new antiearcinoma drugs, Zhang Guo-min et al. synthesized a series of diarylboric α-aminoacid derivatives. These derivatives show good antiearcinoma activities in in vitro studies. Wu Zi-wu et al. reported the single crystal structure of bis (m-
基金Project supported by the Science Foundation of Fujian Province.
文摘I. INTRODUCTIONTwo sesquiterpene alkaloids were isolated from the root skin of Tripterygium Wilfordii Hook. f. by Deng Fu-xiao et al., and named euonine (Ⅰ) and wilfomine (Ⅱ), respectively. They show immunosuppressives after their pharmacological activities were studied by Zheng You-lan et al. The other alkaloids, from Tripterygium Wilfordii Hook.
文摘Ⅰ. INTRODUCTION Seven alkaloids were isolated from the roots of Zanthoxylum nitidum by HUANG Zhi-xun et al. The compound C<sub>22</sub>H<sub>21</sub>O<sub>5</sub>N, named 6-methoxy-5, 6-dihydrochelerythrine, was one of the alkaloids. It exhibits medium antitumor activity.We carry out the X-ray structural analysis of the drug in order to study the relation between the molecular structure and its antitumor activities.
