经前期综合征肝气逆证患者月经周期血清雌二醇、孕酮含量的动态变化

目的:探明卵巢激素水平变化在经前期综合征(PMS)特定亚型发病机理中的作用与影响,揭示PMS肝气逆证部分微观机制。方法:采用放射免疫法检测月经周期不同时相雌二醇(E2)、孕酮(P)含量的动态变化。结果:PMS肝气逆证组E2、P卵泡期分泌峰值明显减低,黄体期的分泌峰值未有形成。结论:E2、P卵泡期分泌高峰的低平与黄体期分泌峰的阙如是PMS肝气逆证微观机理之一。PMS特定亚型病理生理机制之一可能是E2、P水平持续性低下。

肝气逆肝气郁两证病因流行病学调查及情志致病方式研究

目的探求肝气逆、肝气郁两证的病因以及情志致病的方式。方法采用现况调查法,以青岛、济南及庆云县三地1026例工人、干部、教师和农民为调查对象。结果情志内伤所致病例占两证总人数的55.4%,忿怒悔恨、郁怒怨屈是情志内伤的主要种类,其次为心愿不合、忧思悲伤。结论情志内伤是两证的主要致病因素,多种情志交织共同致病,直接伤肝是情志致病的主要方式。

经前期综合征证候分布规律的流行病学调查研究

参照国内经前期综合征与相关证候诊断标准，对山东地区不同职业成年女性人群本病证临床表现进行流行病学调查，对５２６例完整资料详细辨证分析，结果表明：本病证候分布明朗，呈现以肝疏泄失常证为主的规律，肝气逆、肝气郁、肝火上炎与心脾两虚四证覆盖本病９５％，前两证分别占５８．９％与２７．５％，是其主证与常见证。表明此病与肝关系最为密切。

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome (PMS) and reveal partial microcosmic mechanisms of adverse flow of liver-qi. Methods: Estradiol (E2) and progesterone (P) levels in serum were determined at different phases of menstrual cycle by radioimmunoassay. Results: In the group of PMS with adverse flow of liver-qi, the secretive peak value of E2 and P at the follicular phase significantly decreased, and the secretive peak value at the luteal phase did not come into being. Conclusions: Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi. One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2 and P.