Objective: To study the relationship of the expression of P glycoprotein (P gp) in hepatocellular carcinoma (HCC) to invasion and intrahepatic metastasis Methods: Surgical samples of 47 patients with HCC were inve...Objective: To study the relationship of the expression of P glycoprotein (P gp) in hepatocellular carcinoma (HCC) to invasion and intrahepatic metastasis Methods: Surgical samples of 47 patients with HCC were investigated using immunohistochemical method in combination with computer imaging analytic technique Results: In HCC, anti P gp immunostaining was mainly localized in the cellular membrane A significantly higher positive percentage of P gp expression was observed in HCC tissues than normal liver tissues ( P <0 01) HCCs with intrahepatic metastasis had a significantly higher P gp expression level than those without intrahepatic metastasis ( P <0 01) The expression level of P gp in HCCs with invasion was significantly higher than that in HCCs without invasion ( P <0 05) Conclusion: P gp may play an important role in the invasion and intrahepatic metastasis of HCC P gp expression level in tumor correlates the progression of HCC展开更多
文摘Objective: To study the relationship of the expression of P glycoprotein (P gp) in hepatocellular carcinoma (HCC) to invasion and intrahepatic metastasis Methods: Surgical samples of 47 patients with HCC were investigated using immunohistochemical method in combination with computer imaging analytic technique Results: In HCC, anti P gp immunostaining was mainly localized in the cellular membrane A significantly higher positive percentage of P gp expression was observed in HCC tissues than normal liver tissues ( P <0 01) HCCs with intrahepatic metastasis had a significantly higher P gp expression level than those without intrahepatic metastasis ( P <0 01) The expression level of P gp in HCCs with invasion was significantly higher than that in HCCs without invasion ( P <0 05) Conclusion: P gp may play an important role in the invasion and intrahepatic metastasis of HCC P gp expression level in tumor correlates the progression of HCC