In terms of metabolic experimental facts and calculation of quantum chemical parameters on catabolic intermediate and with extrathermodynamic method by taking it as a medium with the structure-carcinogenic activity re...In terms of metabolic experimental facts and calculation of quantum chemical parameters on catabolic intermediate and with extrathermodynamic method by taking it as a medium with the structure-carcinogenic activity relationship (SCAR) of parent polycyclic aromatic hydrocarbons (PAH), we have evidenced the importance of di-functional cross-linking between the double strands of complementary DNA base-pairs for complete carcinogenesis. We have discussed quantitatively the comprehensive catabolic展开更多
文摘In terms of metabolic experimental facts and calculation of quantum chemical parameters on catabolic intermediate and with extrathermodynamic method by taking it as a medium with the structure-carcinogenic activity relationship (SCAR) of parent polycyclic aromatic hydrocarbons (PAH), we have evidenced the importance of di-functional cross-linking between the double strands of complementary DNA base-pairs for complete carcinogenesis. We have discussed quantitatively the comprehensive catabolic