目的:采用Meta分析评价含锶脱敏牙膏对牙本质过敏症(DH)的治疗效果,为临床治疗提供参考。方法:收集1990年1月1日至2020年3月1日PubMed,EMBASE,Web of Science,CENTRAL和CNKI等数据库关于研究含锶脱敏牙膏对DH的随机对照试验(RCT)文献,运...目的:采用Meta分析评价含锶脱敏牙膏对牙本质过敏症(DH)的治疗效果,为临床治疗提供参考。方法:收集1990年1月1日至2020年3月1日PubMed,EMBASE,Web of Science,CENTRAL和CNKI等数据库关于研究含锶脱敏牙膏对DH的随机对照试验(RCT)文献,运用Stata 14.0软件对提取的所有文献数据进行Meta分析。结果:共纳入8篇RCT文献,根据8项研究的最长试验周期,对含锶脱敏牙膏和对照组牙膏干预后进行探诊及空气喷吹检测差异进行Meta分析,试验组与对照组在探诊、空气检测敏感值之间比较,差异均无统计学意义(P>0.05);根据试验时间长短、结局指标分类,分别合并即刻、≤1、2、4、6、8、12周的探诊敏感、空气检测敏感值进行亚组分析,结果显示试验组与对照组在探诊、空气检测敏感值之间比较,差异均无统计学意义(P>0.05)。结论:含锶脱敏牙膏和对照组牙膏相比,不能更有效地减轻DH,需要更多的研究来进一步验证其对缓解DH的效果。展开更多
The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into ...The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into unexplored realms and accelerating progress in life sciences and medicine.CRISPR-based gene screening,recognized for its efficiency and practicality,is widely utilized across diverse biological fields.Aging is a multifaceted process governed by a myriad of genetic and epigenetic factors.Unraveling the genes regulating aging holds promise for understanding this intricate phenomenon and devising strategies for its assessment and intervention.This review provides a comprehensive overview of the progress in CRISPR screening and its applications in aging research,while also offering insights into future directions.CRISPR-based genetic-manipulation tools are positioned as indispensable instruments for mitigating aging and managing age-related diseases.展开更多
文摘目的:采用Meta分析评价含锶脱敏牙膏对牙本质过敏症(DH)的治疗效果,为临床治疗提供参考。方法:收集1990年1月1日至2020年3月1日PubMed,EMBASE,Web of Science,CENTRAL和CNKI等数据库关于研究含锶脱敏牙膏对DH的随机对照试验(RCT)文献,运用Stata 14.0软件对提取的所有文献数据进行Meta分析。结果:共纳入8篇RCT文献,根据8项研究的最长试验周期,对含锶脱敏牙膏和对照组牙膏干预后进行探诊及空气喷吹检测差异进行Meta分析,试验组与对照组在探诊、空气检测敏感值之间比较,差异均无统计学意义(P>0.05);根据试验时间长短、结局指标分类,分别合并即刻、≤1、2、4、6、8、12周的探诊敏感、空气检测敏感值进行亚组分析,结果显示试验组与对照组在探诊、空气检测敏感值之间比较,差异均无统计学意义(P>0.05)。结论:含锶脱敏牙膏和对照组牙膏相比,不能更有效地减轻DH,需要更多的研究来进一步验证其对缓解DH的效果。
文摘The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into unexplored realms and accelerating progress in life sciences and medicine.CRISPR-based gene screening,recognized for its efficiency and practicality,is widely utilized across diverse biological fields.Aging is a multifaceted process governed by a myriad of genetic and epigenetic factors.Unraveling the genes regulating aging holds promise for understanding this intricate phenomenon and devising strategies for its assessment and intervention.This review provides a comprehensive overview of the progress in CRISPR screening and its applications in aging research,while also offering insights into future directions.CRISPR-based genetic-manipulation tools are positioned as indispensable instruments for mitigating aging and managing age-related diseases.