Hybrid braids of polyglycolide （PGA） and chitosan were prepared by the three-yarn braiding method from PGA and chitosan fiber bundles. These braids were in vitro degraded by incubating them in phosphate buffered sal...Hybrid braids of polyglycolide （PGA） and chitosan were prepared by the three-yarn braiding method from PGA and chitosan fiber bundles. These braids were in vitro degraded by incubating them in phosphate buffered saline （PBS） at pH 7.4 and 37 ℃ for 5 weeks. Results suggested that PGA/chitosan hybrid braids degraded significantly. Scanning electron micrographs showed that chitosan fibers in the PGA/chitosan hybrid braid with about 7500 PGA in weight （PGA75/chitosan） were shaped into gel-like after 5 weeks, but those in the hybrid braid with about 2500 PGA in weight （PGA25/chitosan） did not change. After 5 weeks, the ultimate tensile loads of PGA and PGA75/chitosan braids lost almost completely, but those of chitosan and PGA25/chitosan braids remained around 14 N. The PGA/chitosan hybrid braids with higher initial ultimate tensile load would have potential applications in tendon/ligament tissue reconstruction.展开更多
基金Supported by the Cooperative Project Between Nankai University and Tianjin University, Ministry of EducationScientific Research Starting Fund for Homecoming Scholars, Ministry of Education.
文摘Hybrid braids of polyglycolide （PGA） and chitosan were prepared by the three-yarn braiding method from PGA and chitosan fiber bundles. These braids were in vitro degraded by incubating them in phosphate buffered saline （PBS） at pH 7.4 and 37 ℃ for 5 weeks. Results suggested that PGA/chitosan hybrid braids degraded significantly. Scanning electron micrographs showed that chitosan fibers in the PGA/chitosan hybrid braid with about 7500 PGA in weight （PGA75/chitosan） were shaped into gel-like after 5 weeks, but those in the hybrid braid with about 2500 PGA in weight （PGA25/chitosan） did not change. After 5 weeks, the ultimate tensile loads of PGA and PGA75/chitosan braids lost almost completely, but those of chitosan and PGA25/chitosan braids remained around 14 N. The PGA/chitosan hybrid braids with higher initial ultimate tensile load would have potential applications in tendon/ligament tissue reconstruction.
