为阐明胃癌根治术中联合切脾与否对机体整体免疫状态所起的影响,本文对比 AGC 患者R^+_2(保脾)与 R_3(切脾)根治术后外周血中 NK 细胞活性与 T 细胞亚群值的变化。结果表明:(1)与正常人相比,AGC 患者的术前 CD_8^+细胞值明显升高,而 NK...为阐明胃癌根治术中联合切脾与否对机体整体免疫状态所起的影响,本文对比 AGC 患者R^+_2(保脾)与 R_3(切脾)根治术后外周血中 NK 细胞活性与 T 细胞亚群值的变化。结果表明:(1)与正常人相比,AGC 患者的术前 CD_8^+细胞值明显升高,而 NK 细胞活性、CD^+_3、AD^+_4、CD^+_4/CD^+_8细胞比值均显著降低(P<0.05～0.001)。(2)R^+_2或 R_3患者术后的 NK 细胞、CD_4^+细胞及 CD_4^+/CD_8^+细胞比值均见明显回升(P<0.05～0.005),但 R_3者的CD_8^+细胞值亦同时有明显的下降(P<0.01)。(3)作 R_2^+或 R_3者术后近期或远期 NK 细胞活性与 T 细胞亚群值均无差异(P>0.1～0.5)。提示 AGC 患者的免疫功能因有肿瘤负荷存在而受到明显抑制;切除病灶可对机体正性免疫功能的恢复起决定性作用;如属必要,于 AGC 患者作联合脾脏切除对整体免疫状态并无明显的不利影响。展开更多
Natural Killer (NK) cell activity, T-lymphocyte subsets and circulating im-mune complexes (CIC) were determinated in samples of peripheral blood (PB),splenicvenous blood(SVB) ac scenic blood (SB) from 39 AGC pati...Natural Killer (NK) cell activity, T-lymphocyte subsets and circulating im-mune complexes (CIC) were determinated in samples of peripheral blood (PB),splenicvenous blood(SVB) ac scenic blood (SB) from 39 AGC patients undergoing operation(22 with splenectomy,17 without splenectomy), and in samples of PB fromninety-eight healthy adults as controls. The results showed. (1) The NK activity ofperipheral plood lymphocytes (PBAs), splenic venous blood lymphocytes (SVLs) andsplenic cells (SCs) of the patients were lower than that of PBLs controls (highlysignificant): (2) The NK activity of SVAs ed SCs of AGC pothots were thesignihetly lower than that of their own PBLs; (3) Compared with the PBLs of normalcontrols, the SVLs and SCs of the pothots demonstrated a significant fall in CD3+ andCD4+ cells,and a significant increase in CD8+ cells, resulting in an important declinein CD4+/CM8+ cell ratio; (4) Significant declaim in CD4+/CD8+ cell ratio was ofsonoted in SVAs and SCs of AGC pothots when comas with that of their own PBAs,mainly caused by a marked decrease in CD4+ cells, (5) Sera fromPB, SVB and SB of the potients all showed significantly higher CIC valeal taan the serafrom the PB of healthy PB of healthy controls. In conclusion,the spleen appears to exert animmunosuppressive effect in the AGC poticnts, combained splenectomy can thus berightfully included in the resection when indication is present.展开更多
文摘为阐明胃癌根治术中联合切脾与否对机体整体免疫状态所起的影响,本文对比 AGC 患者R^+_2(保脾)与 R_3(切脾)根治术后外周血中 NK 细胞活性与 T 细胞亚群值的变化。结果表明:(1)与正常人相比,AGC 患者的术前 CD_8^+细胞值明显升高,而 NK 细胞活性、CD^+_3、AD^+_4、CD^+_4/CD^+_8细胞比值均显著降低(P<0.05～0.001)。(2)R^+_2或 R_3患者术后的 NK 细胞、CD_4^+细胞及 CD_4^+/CD_8^+细胞比值均见明显回升(P<0.05～0.005),但 R_3者的CD_8^+细胞值亦同时有明显的下降(P<0.01)。(3)作 R_2^+或 R_3者术后近期或远期 NK 细胞活性与 T 细胞亚群值均无差异(P>0.1～0.5)。提示 AGC 患者的免疫功能因有肿瘤负荷存在而受到明显抑制;切除病灶可对机体正性免疫功能的恢复起决定性作用;如属必要,于 AGC 患者作联合脾脏切除对整体免疫状态并无明显的不利影响。
文摘Natural Killer (NK) cell activity, T-lymphocyte subsets and circulating im-mune complexes (CIC) were determinated in samples of peripheral blood (PB),splenicvenous blood(SVB) ac scenic blood (SB) from 39 AGC patients undergoing operation(22 with splenectomy,17 without splenectomy), and in samples of PB fromninety-eight healthy adults as controls. The results showed. (1) The NK activity ofperipheral plood lymphocytes (PBAs), splenic venous blood lymphocytes (SVLs) andsplenic cells (SCs) of the patients were lower than that of PBLs controls (highlysignificant): (2) The NK activity of SVAs ed SCs of AGC pothots were thesignihetly lower than that of their own PBLs; (3) Compared with the PBLs of normalcontrols, the SVLs and SCs of the pothots demonstrated a significant fall in CD3+ andCD4+ cells,and a significant increase in CD8+ cells, resulting in an important declinein CD4+/CM8+ cell ratio; (4) Significant declaim in CD4+/CD8+ cell ratio was ofsonoted in SVAs and SCs of AGC pothots when comas with that of their own PBAs,mainly caused by a marked decrease in CD4+ cells, (5) Sera fromPB, SVB and SB of the potients all showed significantly higher CIC valeal taan the serafrom the PB of healthy PB of healthy controls. In conclusion,the spleen appears to exert animmunosuppressive effect in the AGC poticnts, combained splenectomy can thus berightfully included in the resection when indication is present.
