【目的】探讨马齿苋多糖(Polysaccharide of Portulaca oleracea L.,POP)对糖尿病小鼠糖、脂代谢相关因子的影响,为POP的开发利用提供依据。【方法】采用饲喂高糖高脂日粮并注射链脲佐菌素(STZ)的方法,诱导Ⅱ型糖尿病(NIDDM)小鼠动物模...【目的】探讨马齿苋多糖(Polysaccharide of Portulaca oleracea L.,POP)对糖尿病小鼠糖、脂代谢相关因子的影响,为POP的开发利用提供依据。【方法】采用饲喂高糖高脂日粮并注射链脲佐菌素(STZ)的方法,诱导Ⅱ型糖尿病(NIDDM)小鼠动物模型,然后将其分为正常对照组、模型对照组、POP低剂量灌胃组(POP用量100mg/kg)、POP高剂量灌胃组(POP用量200mg/kg)和罗格列酮灌胃组(罗格列酮用量3mg/kg),连续灌胃28d后,将小鼠断头处死,采集肾组织,检测蛋白激酶B(PKB)、PKC、过氧化物酶体增殖物激活受体γ(PPARγ)等糖脂代谢相关因子在糖尿病小鼠肾脏中表达量的变化。【结果】与模型对照组相比,其余各组小鼠肾组织PKB蛋白、PPARγ蛋白表达量均显著增加(P<0.05),正常对照组、POP高剂量灌胃组和罗格列酮灌胃组小鼠肾组织PKC蛋白表达量显著降低(P<0.05)。【结论】POP能上调NIDDM小鼠PKB、PPARγ基因的表达,能下调PKC基因的表达,从而发挥降低血糖的作用。展开更多
Software architecture has changed the way of programming by shifting developers′ focus from lines-of-codeto coarser-grained architectureal elements and their interconneetion structure. Furthermore, a flexible archite...Software architecture has changed the way of programming by shifting developers′ focus from lines-of-codeto coarser-grained architectureal elements and their interconneetion structure. Furthermore, a flexible architecturemakes it easier to identify and evolve the elements involved in a change. In this paper,we present a common messge-based framework which simplifies programming and is flexible to accommodate architecutral changes. A case studysuggests that our framework effectively aids in both program constructiong and software evolution.展开更多
The technology of virtual data warehouses catches more and more interests of people. In this paper,aQuery-Optimization Based Virtual Data Warehouse (QVDW)model is presented,which not only has all the advantagesthat a ...The technology of virtual data warehouses catches more and more interests of people. In this paper,aQuery-Optimization Based Virtual Data Warehouse (QVDW)model is presented,which not only has all the advantagesthat a virtual data warehouse has,but also can change bottom layer data structures and the model itself according tousers' various query requests. The aim is to offer customized service to OLAP (on-line analysis processing)users.展开更多
文摘【目的】探讨马齿苋多糖(Polysaccharide of Portulaca oleracea L.,POP)对糖尿病小鼠糖、脂代谢相关因子的影响,为POP的开发利用提供依据。【方法】采用饲喂高糖高脂日粮并注射链脲佐菌素(STZ)的方法,诱导Ⅱ型糖尿病(NIDDM)小鼠动物模型,然后将其分为正常对照组、模型对照组、POP低剂量灌胃组(POP用量100mg/kg)、POP高剂量灌胃组(POP用量200mg/kg)和罗格列酮灌胃组(罗格列酮用量3mg/kg),连续灌胃28d后,将小鼠断头处死,采集肾组织,检测蛋白激酶B(PKB)、PKC、过氧化物酶体增殖物激活受体γ(PPARγ)等糖脂代谢相关因子在糖尿病小鼠肾脏中表达量的变化。【结果】与模型对照组相比,其余各组小鼠肾组织PKB蛋白、PPARγ蛋白表达量均显著增加(P<0.05),正常对照组、POP高剂量灌胃组和罗格列酮灌胃组小鼠肾组织PKC蛋白表达量显著降低(P<0.05)。【结论】POP能上调NIDDM小鼠PKB、PPARγ基因的表达,能下调PKC基因的表达,从而发挥降低血糖的作用。
文摘Software architecture has changed the way of programming by shifting developers′ focus from lines-of-codeto coarser-grained architectureal elements and their interconneetion structure. Furthermore, a flexible architecturemakes it easier to identify and evolve the elements involved in a change. In this paper,we present a common messge-based framework which simplifies programming and is flexible to accommodate architecutral changes. A case studysuggests that our framework effectively aids in both program constructiong and software evolution.
文摘The technology of virtual data warehouses catches more and more interests of people. In this paper,aQuery-Optimization Based Virtual Data Warehouse (QVDW)model is presented,which not only has all the advantagesthat a virtual data warehouse has,but also can change bottom layer data structures and the model itself according tousers' various query requests. The aim is to offer customized service to OLAP (on-line analysis processing)users.
