Modern cellular pathology relies on conventional microscopes to study the etiology and pathogenesis of diseases,which suffer from limited spatial resolution,little dynamic information due to sample fixation,and the la...Modern cellular pathology relies on conventional microscopes to study the etiology and pathogenesis of diseases,which suffer from limited spatial resolution,little dynamic information due to sample fixation,and the lack of molecular information.For example,Pelizaeus-Merzbacher disease(PMD)is a genetic disorder of the central nervous system caused by different duplications or mutations of the proteolipid protein 1 gene(PLP1)in oligodendrocytes,which leads to hypomyelination and leukodystrophy in patients classified into either classical,transitional,or connatal phenotype[1].However,the correlations between genotypes and phenotypes at cellular level remain elusive.展开更多
基金supported by the National Natural Science Foundation of China (81925022, 31821091, 31327901, 91854112, and 91750203)the National Key Research and Development Program of China (SQ2016YFJC040028, 2016YFC1306201 and 2016YFC0901505)+1 种基金the Beijing Natural Science Foundation (L172003)the UMHSPUHSC Joint Institute for Translational and Clinical Research (BMU2019JI009)。
文摘Modern cellular pathology relies on conventional microscopes to study the etiology and pathogenesis of diseases,which suffer from limited spatial resolution,little dynamic information due to sample fixation,and the lack of molecular information.For example,Pelizaeus-Merzbacher disease(PMD)is a genetic disorder of the central nervous system caused by different duplications or mutations of the proteolipid protein 1 gene(PLP1)in oligodendrocytes,which leads to hypomyelination and leukodystrophy in patients classified into either classical,transitional,or connatal phenotype[1].However,the correlations between genotypes and phenotypes at cellular level remain elusive.
