癫痫(epilepsy)是一种由多种病因导致的大脑神经元高度同步化异常放电所致的慢性脑功能障碍综合征,未经过系统治疗的癫痫患者生活质量普遍较低。单细胞测序是在单个细胞分辨率下对遗传信息进行测序,相比于传统测序更加准确,可以对细胞...癫痫(epilepsy)是一种由多种病因导致的大脑神经元高度同步化异常放电所致的慢性脑功能障碍综合征,未经过系统治疗的癫痫患者生活质量普遍较低。单细胞测序是在单个细胞分辨率下对遗传信息进行测序,相比于传统测序更加准确,可以对细胞进行无偏见地分类、构建细胞图谱,为癫痫疾病的研究提供新途径。本文主要介绍单细胞测序技术的发展及在癫痫疾病中的应用现状,并对其发展前景进行展望。Epilepsy is a chronic brain dysfunction syndrome caused by highly synchronized abnormal discharge of brain neurons caused by various causes. The quality of life of epilepsy patients without systemic treatment is generally lower. Single cell sequencing is to sequence genetic information at the resolution of a single cell, which is more accurate than traditional sequencing, and can classify cells without bias and construct cell maps. It can provide a new way for the study of epilepsy disease. In this paper, the development of single cell sequencing technology and its application in epilepsy are introduced, and its development prospect is prospected.展开更多
文摘癫痫(epilepsy)是一种由多种病因导致的大脑神经元高度同步化异常放电所致的慢性脑功能障碍综合征,未经过系统治疗的癫痫患者生活质量普遍较低。单细胞测序是在单个细胞分辨率下对遗传信息进行测序,相比于传统测序更加准确,可以对细胞进行无偏见地分类、构建细胞图谱,为癫痫疾病的研究提供新途径。本文主要介绍单细胞测序技术的发展及在癫痫疾病中的应用现状,并对其发展前景进行展望。Epilepsy is a chronic brain dysfunction syndrome caused by highly synchronized abnormal discharge of brain neurons caused by various causes. The quality of life of epilepsy patients without systemic treatment is generally lower. Single cell sequencing is to sequence genetic information at the resolution of a single cell, which is more accurate than traditional sequencing, and can classify cells without bias and construct cell maps. It can provide a new way for the study of epilepsy disease. In this paper, the development of single cell sequencing technology and its application in epilepsy are introduced, and its development prospect is prospected.
