目的 提高对新型布尼亚病毒感染患者的流行病学、临床特征、病变特点及其治疗的认识.方法 回顾性分析2011年5-7月浙江省舟山医院收治的5例重症新型布尼亚病毒感染患者临床资料,并结合相关文献对该病的临床特点进行分析.结果 5例重型患...目的 提高对新型布尼亚病毒感染患者的流行病学、临床特征、病变特点及其治疗的认识.方法 回顾性分析2011年5-7月浙江省舟山医院收治的5例重症新型布尼亚病毒感染患者临床资料,并结合相关文献对该病的临床特点进行分析.结果 5例重型患者典型临床表现为持续高热、全身肌肉酸痛、浅表淋巴结肿大、腹痛、腹泻伴消化道出血、血小板及白细胞进行性下降.白细胞和血小板可分别降至1.0×109/l和30×109/l以下,血小板在发病的第9～19天降至最低,随后1周左右恢复至正常.病程第7～10天,患者cd4+和cd8+t淋巴细胞数量急剧下降.结论 该病多发生于丘陵地区的中老年人.患者起病急,病情重,重症者易发生心、肝、肾等脏器功能损害.除蜱叮咬外,可能还有其他传播方式.
abstract：
objective to review the epidemiology,clinical characteristics,pathological changes and treatment of severe fever with thrombocytopenia syndrome (sfts) associated with the novel bunyavirus infection.methods clinical data of five cases of sfts from zhoushan hospital during may,2011 and july,2011 were retrospectively analyzed,and related literatures were also reviewed.results persistent high fever,sore muscles,enlarged superficial lymph nodes,abdominal pain,diarrhea with gastrointestinal hemorrhage,progressive decrease of phtelets and white blood cells were observed.the platelets deceased to 30 × 109/l during d9 and d19 after the onset,and recovered in about one week later.the white cells deceased to 1.0 x 109/l.cd4+ t and cd8+ t lymphocytes decreased remarkably during d7 and d10 after the onset.conclusions sfts usually occurs in middle and old aged people from hilly region.it is severe and has abrupt onset.damages on heart,liver and kidney may occur.in addition to tick bite,there may be other transmission ways.展开更多
目的 研究血清总胆汁酸(tba)水平与慢性肝病患者肝组织炎症分级间的量化关系.方法 用循环酶法检测172例各类慢性肝病患者血清tba水平,并进行肝组织病理活检,以确定炎症分级.采用spss12.0软件包分析tba与肝组织炎症分级之间的量化对应关...目的 研究血清总胆汁酸(tba)水平与慢性肝病患者肝组织炎症分级间的量化关系.方法 用循环酶法检测172例各类慢性肝病患者血清tba水平,并进行肝组织病理活检,以确定炎症分级.采用spss12.0软件包分析tba与肝组织炎症分级之间的量化对应关系.结果 血清tba水平与肝组织炎症分级呈正相关(r=0.275,p＜0.01)；当tba达到20 μmol/l时,肝组织炎症分级达到g2水平.结论 血清tba水平在评估慢性肝病患者肝组织炎症分级方面具有重要意义.
abstract：
objective to investigate the correlation of serum total bile acid (tba) levels with the inflammation grades of liver tissue in chronic liver diseases.methods cyclophorase assay was used to detect the serum tba levels in 172 patients with various chronic liver diseases,and the inflammation grades of liver tissue were determined by liver biopsy.the correlation between serum tba levels and the inflammation grades of liver tissue was evaluated using spss 12.0 software.results serum tba level was positively correlated with the inflammation grade of liver tissue ( r =0.275,p ＜ 0.01 ).the inflammation grade reached g2 when serum tba was 20 μmol/l.conclusion serum tba level may be useful for evaluating the inflammation grade of liver tissue in chronic liver diseases.展开更多
文摘目的 提高对新型布尼亚病毒感染患者的流行病学、临床特征、病变特点及其治疗的认识.方法 回顾性分析2011年5-7月浙江省舟山医院收治的5例重症新型布尼亚病毒感染患者临床资料,并结合相关文献对该病的临床特点进行分析.结果 5例重型患者典型临床表现为持续高热、全身肌肉酸痛、浅表淋巴结肿大、腹痛、腹泻伴消化道出血、血小板及白细胞进行性下降.白细胞和血小板可分别降至1.0×109/l和30×109/l以下,血小板在发病的第9～19天降至最低,随后1周左右恢复至正常.病程第7～10天,患者cd4+和cd8+t淋巴细胞数量急剧下降.结论 该病多发生于丘陵地区的中老年人.患者起病急,病情重,重症者易发生心、肝、肾等脏器功能损害.除蜱叮咬外,可能还有其他传播方式.
abstract：
objective to review the epidemiology,clinical characteristics,pathological changes and treatment of severe fever with thrombocytopenia syndrome (sfts) associated with the novel bunyavirus infection.methods clinical data of five cases of sfts from zhoushan hospital during may,2011 and july,2011 were retrospectively analyzed,and related literatures were also reviewed.results persistent high fever,sore muscles,enlarged superficial lymph nodes,abdominal pain,diarrhea with gastrointestinal hemorrhage,progressive decrease of phtelets and white blood cells were observed.the platelets deceased to 30 × 109/l during d9 and d19 after the onset,and recovered in about one week later.the white cells deceased to 1.0 x 109/l.cd4+ t and cd8+ t lymphocytes decreased remarkably during d7 and d10 after the onset.conclusions sfts usually occurs in middle and old aged people from hilly region.it is severe and has abrupt onset.damages on heart,liver and kidney may occur.in addition to tick bite,there may be other transmission ways.
文摘目的 研究血清总胆汁酸(tba)水平与慢性肝病患者肝组织炎症分级间的量化关系.方法 用循环酶法检测172例各类慢性肝病患者血清tba水平,并进行肝组织病理活检,以确定炎症分级.采用spss12.0软件包分析tba与肝组织炎症分级之间的量化对应关系.结果 血清tba水平与肝组织炎症分级呈正相关(r=0.275,p＜0.01)；当tba达到20 μmol/l时,肝组织炎症分级达到g2水平.结论 血清tba水平在评估慢性肝病患者肝组织炎症分级方面具有重要意义.
abstract：
objective to investigate the correlation of serum total bile acid (tba) levels with the inflammation grades of liver tissue in chronic liver diseases.methods cyclophorase assay was used to detect the serum tba levels in 172 patients with various chronic liver diseases,and the inflammation grades of liver tissue were determined by liver biopsy.the correlation between serum tba levels and the inflammation grades of liver tissue was evaluated using spss 12.0 software.results serum tba level was positively correlated with the inflammation grade of liver tissue ( r =0.275,p ＜ 0.01 ).the inflammation grade reached g2 when serum tba was 20 μmol/l.conclusion serum tba level may be useful for evaluating the inflammation grade of liver tissue in chronic liver diseases.
