青光眼是一种以进行性视力丧失为特征的神经退行性疾病,主要由视网膜神经节细胞功能障碍和死亡引起。该病的发病机制较为复杂。近年来,青光眼被提出可能是一种自身免疫性疾病。已有研究证实,免疫介导的神经退行性变化对青光眼的发生、...青光眼是一种以进行性视力丧失为特征的神经退行性疾病,主要由视网膜神经节细胞功能障碍和死亡引起。该病的发病机制较为复杂。近年来,青光眼被提出可能是一种自身免疫性疾病。已有研究证实,免疫介导的神经退行性变化对青光眼的发生、发展中起着重要作用。其中免疫细胞、自身抗体、补体系统以及小胶质细胞都参与了其病理过程。因此,本文就上述因素的变化与青光眼的关系作一综述,主要是关于近年来青光眼的免疫调节研究方向,以便更深入地了解青光眼的发病机制,从而为临床治疗提供更有效的方法,并为提高患者的生活质量提供参考。Glaucoma is a neurodegenerative disease characterized by progressive vision loss, which is primarily caused by retinal ganglion cells dysfunction and death. The pathogenesis of this disease is complicated. In recent years, glaucoma has been proposed a kind of autoimmune disease. The role of immune-mediated neurodegeneration in glaucoma has been demonstrated, which is an important part of the pathogenesis of glaucoma. Immune cells, autoantibodies, the complement system, proinflammatory mediators, and microglia are all involved in the pathogenesis. Therefore, the main aim of this review was to summarize the current knowledge about changes of above factors and their association with glaucoma, mainly focusing on the research direction of glaucomatous immune regulation in recent years, as a better understanding of its pathogenesis will greatly promote progress toward more effective methods for clinical treatment and improve the life quality of patients.展开更多
文摘青光眼是一种以进行性视力丧失为特征的神经退行性疾病,主要由视网膜神经节细胞功能障碍和死亡引起。该病的发病机制较为复杂。近年来,青光眼被提出可能是一种自身免疫性疾病。已有研究证实,免疫介导的神经退行性变化对青光眼的发生、发展中起着重要作用。其中免疫细胞、自身抗体、补体系统以及小胶质细胞都参与了其病理过程。因此,本文就上述因素的变化与青光眼的关系作一综述,主要是关于近年来青光眼的免疫调节研究方向,以便更深入地了解青光眼的发病机制,从而为临床治疗提供更有效的方法,并为提高患者的生活质量提供参考。Glaucoma is a neurodegenerative disease characterized by progressive vision loss, which is primarily caused by retinal ganglion cells dysfunction and death. The pathogenesis of this disease is complicated. In recent years, glaucoma has been proposed a kind of autoimmune disease. The role of immune-mediated neurodegeneration in glaucoma has been demonstrated, which is an important part of the pathogenesis of glaucoma. Immune cells, autoantibodies, the complement system, proinflammatory mediators, and microglia are all involved in the pathogenesis. Therefore, the main aim of this review was to summarize the current knowledge about changes of above factors and their association with glaucoma, mainly focusing on the research direction of glaucomatous immune regulation in recent years, as a better understanding of its pathogenesis will greatly promote progress toward more effective methods for clinical treatment and improve the life quality of patients.
