目的通过网络药理学方法研究夏枯草-半夏治疗弥漫大B细胞淋巴瘤(Diffuse large B-cell lymphoma,DLBCL)的潜在分子机制。方法首先利用中药系统药理学数据库和分析平台(Traditional Chinese medicine system platform,TCMSP)筛选夏枯草-...目的通过网络药理学方法研究夏枯草-半夏治疗弥漫大B细胞淋巴瘤(Diffuse large B-cell lymphoma,DLBCL)的潜在分子机制。方法首先利用中药系统药理学数据库和分析平台(Traditional Chinese medicine system platform,TCMSP)筛选夏枯草-半夏的活性成分及其对应的靶基因。其次,通过GeneCards、OMIM、TTD、DrugBank等数据库搜索DLBCL的疾病靶点,取交集后得到夏枯草-半夏治疗DLBCL的共同靶标基因,将共同靶标基因导入Cytoscape构建“夏枯草-半夏活性成分-DLBCL靶标基因”关系网络图。再通过PPI网络分析,筛选核心靶基因,进行基因本体论和京都基因与基因组百科全书通路分析。结果夏枯草-半夏治疗DLBCL的主要活性成分有13种,包括槲皮素、β-谷甾醇、豆甾醇等;其作用的核心靶点包括AKT1、JUN、TP53、MAPK1、TNF等;其主要通过调节PI3K-Akt信号通路、TNF信号通路等信号通路发挥治疗DLBCL的作用。结论夏枯草-半夏可通过多靶标、多途径发挥辅助治疗DLBCL的作用。展开更多
Translation can not exist alone. It must be carried out by its agent that is under multiple influence of history, culture,power and other social elements for he is exactly the product of society. Meanwhile, those elem...Translation can not exist alone. It must be carried out by its agent that is under multiple influence of history, culture,power and other social elements for he is exactly the product of society. Meanwhile, those elements also change and evolve with the development of translation. The relationship between them can be considered as rather delicate and sophisticated.展开更多
文摘目的通过网络药理学方法研究夏枯草-半夏治疗弥漫大B细胞淋巴瘤(Diffuse large B-cell lymphoma,DLBCL)的潜在分子机制。方法首先利用中药系统药理学数据库和分析平台(Traditional Chinese medicine system platform,TCMSP)筛选夏枯草-半夏的活性成分及其对应的靶基因。其次,通过GeneCards、OMIM、TTD、DrugBank等数据库搜索DLBCL的疾病靶点,取交集后得到夏枯草-半夏治疗DLBCL的共同靶标基因,将共同靶标基因导入Cytoscape构建“夏枯草-半夏活性成分-DLBCL靶标基因”关系网络图。再通过PPI网络分析,筛选核心靶基因,进行基因本体论和京都基因与基因组百科全书通路分析。结果夏枯草-半夏治疗DLBCL的主要活性成分有13种,包括槲皮素、β-谷甾醇、豆甾醇等;其作用的核心靶点包括AKT1、JUN、TP53、MAPK1、TNF等;其主要通过调节PI3K-Akt信号通路、TNF信号通路等信号通路发挥治疗DLBCL的作用。结论夏枯草-半夏可通过多靶标、多途径发挥辅助治疗DLBCL的作用。
文摘Translation can not exist alone. It must be carried out by its agent that is under multiple influence of history, culture,power and other social elements for he is exactly the product of society. Meanwhile, those elements also change and evolve with the development of translation. The relationship between them can be considered as rather delicate and sophisticated.