Step-coupler waveguide-integrated Ge/Si avalanche photodetector(APD) is based on the vertical multimode interference(MMI), enhancing light scattering towards the Ge active region and creating mirror images of optical ...Step-coupler waveguide-integrated Ge/Si avalanche photodetector(APD) is based on the vertical multimode interference(MMI), enhancing light scattering towards the Ge active region and creating mirror images of optical modes close to the Ge layer. However, there are two ineluctable contact angels between selectively epitaxial growth Ge and Si layers and selectively epitaxial growth Si and Si substrate, which has an effect on the coupling efficiency and the absorption of the photodetector. Therefore, step-coupled Ge/Si avalanche photodetectors with different step lengths are designed and fabricated. It is found that responsivity of APDs with step-coupler-length of 3.0 μm is 0.51 A/W at-6 V, 21% higher than that of 1.5 μm, which matches well with simulation absorption. The multiplication gain factor is as high as 50, and the maximum gain-bandwidth product reaches up to 376 GHz.展开更多
目的:探讨Gene Xper t法检测痰液在肺结核诊断中的临床价值。方法:选取2020年12月—2021年3月在滨州市结核病防治院确诊的住院肺结核患者123例,123例患者各留取晨痰3~5 m L于无菌痰盒中,分别采用GeneXpert法、痰TB-DNA定性法、痰培养法...目的:探讨Gene Xper t法检测痰液在肺结核诊断中的临床价值。方法:选取2020年12月—2021年3月在滨州市结核病防治院确诊的住院肺结核患者123例,123例患者各留取晨痰3~5 m L于无菌痰盒中,分别采用GeneXpert法、痰TB-DNA定性法、痰培养法、痰抗酸染色涂片法进行检测,对比不同组别中的诊断结果。结果:123例肺结核患者GeneXpert法阳性89例(72.36%),痰TB-DNA定性法阳性76例(61.79%),痰培养法阳性56例(45.53%),痰抗酸染色涂片法阳性49例(39.84%)。GeneXpert法和痰培养法结果比较,差异有统计学意义(χ^(2)=18.293,P<0.001);痰TB-DNA定性法和痰培养法结果比较,差异有统计学意义(χ^(2)=6.539,P=0.011);痰抗酸染色涂片法和痰培养法结果比较,差异无统计学意义(χ^(2)=0.814,P=0.367);GeneXpert法和痰TB-DNA定性法结果比较,差异无统计学意义(χ^(2)=3.11,P=0.078)。123例患者经痰液检测,菌阳组阳性检出率显著高于菌阴组,菌阳和菌阴组GeneXpert法检测结果比较,差异有统计学意义(χ^(2)=18.229,P<0.001)。结论:GeneXpert法检测患者痰液在肺结核诊断中有较高应用价值,且快速、简便,值得临床应用。展开更多
基金Project supported by the National Key Research and Development Program of China(Grant Nos.2016YFB0402502 and 2017YFF0104803)the National Natural Science Foundation of China(Grant Nos.61674140 and 61505003)+2 种基金the Beijing Natural Science Foundation,China(Grant No.4162063)Beijing Education Commission Project(Grant No.SQKM201610005008)the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(Grant No.QYZDY-SSW-JSC022)
文摘Step-coupler waveguide-integrated Ge/Si avalanche photodetector(APD) is based on the vertical multimode interference(MMI), enhancing light scattering towards the Ge active region and creating mirror images of optical modes close to the Ge layer. However, there are two ineluctable contact angels between selectively epitaxial growth Ge and Si layers and selectively epitaxial growth Si and Si substrate, which has an effect on the coupling efficiency and the absorption of the photodetector. Therefore, step-coupled Ge/Si avalanche photodetectors with different step lengths are designed and fabricated. It is found that responsivity of APDs with step-coupler-length of 3.0 μm is 0.51 A/W at-6 V, 21% higher than that of 1.5 μm, which matches well with simulation absorption. The multiplication gain factor is as high as 50, and the maximum gain-bandwidth product reaches up to 376 GHz.
文摘目的:探讨Gene Xper t法检测痰液在肺结核诊断中的临床价值。方法:选取2020年12月—2021年3月在滨州市结核病防治院确诊的住院肺结核患者123例,123例患者各留取晨痰3~5 m L于无菌痰盒中,分别采用GeneXpert法、痰TB-DNA定性法、痰培养法、痰抗酸染色涂片法进行检测,对比不同组别中的诊断结果。结果:123例肺结核患者GeneXpert法阳性89例(72.36%),痰TB-DNA定性法阳性76例(61.79%),痰培养法阳性56例(45.53%),痰抗酸染色涂片法阳性49例(39.84%)。GeneXpert法和痰培养法结果比较,差异有统计学意义(χ^(2)=18.293,P<0.001);痰TB-DNA定性法和痰培养法结果比较,差异有统计学意义(χ^(2)=6.539,P=0.011);痰抗酸染色涂片法和痰培养法结果比较,差异无统计学意义(χ^(2)=0.814,P=0.367);GeneXpert法和痰TB-DNA定性法结果比较,差异无统计学意义(χ^(2)=3.11,P=0.078)。123例患者经痰液检测,菌阳组阳性检出率显著高于菌阴组,菌阳和菌阴组GeneXpert法检测结果比较,差异有统计学意义(χ^(2)=18.229,P<0.001)。结论:GeneXpert法检测患者痰液在肺结核诊断中有较高应用价值,且快速、简便,值得临床应用。
