为提高燃料空气炸弹(Fuel Air Explosive,FAE)装置爆炸抛撒燃料的极限速度并使速度更加平均,在不改变现有装置整体结构的情况下,采用数值模拟的方法研究起爆方式对FAE装置燃料抛撒径向极限速度的影响。使用有限元分析软件的任意拉格朗日...为提高燃料空气炸弹(Fuel Air Explosive,FAE)装置爆炸抛撒燃料的极限速度并使速度更加平均,在不改变现有装置整体结构的情况下,采用数值模拟的方法研究起爆方式对FAE装置燃料抛撒径向极限速度的影响。使用有限元分析软件的任意拉格朗日-欧拉算法对圆台型FAE装置抛撒燃料进行数值模拟,对比单点起爆、多点起爆和近似线起爆情况下相同位置节点的径向抛撒速度变化情况。研究结果表明,对于燃料上的单元而言,距离较近的起爆点设置会对这个单元上燃料的抛撒运动产生抑制效果,近似线起爆的方式可以使云雾抛撒得更加均匀,为FAE爆炸燃料抛撒数值模拟的进一步细化研究奠定了基础。展开更多
Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network...Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.展开更多
以雷笋膳食纤维为研究对象,经纤维素酶和木聚糖酶改性处理,分析其理化性能和结构特征变化。持水力、持油力、膨胀力和吸附能力(亚硝酸盐和胆固醇)为膳食纤维(dietary fiber,DF)理化性能的考察指标,通过扫描电子显微镜(SEM)、傅里叶红外...以雷笋膳食纤维为研究对象,经纤维素酶和木聚糖酶改性处理,分析其理化性能和结构特征变化。持水力、持油力、膨胀力和吸附能力(亚硝酸盐和胆固醇)为膳食纤维(dietary fiber,DF)理化性能的考察指标,通过扫描电子显微镜(SEM)、傅里叶红外光谱(FT-IR)和X-射线衍射(XRD)检测膳食纤维的结构变化。结果表明,酶法改性后,可溶性膳食纤维含量从(1.02±0.04) g/100 g DF增加至(6.80±0.15) g/100 g DF; DF的持水量,持油量和膨胀能力、吸附胆固醇和亚硝酸根离子能力均显著增加(P<0.05)。改性DF的表面孔隙增加、比表面积增大,木质素和纤维素部分降解,结晶度降低。因此,使用纤维素酶和木聚糖酶是一种优良的雷笋DF酶法改性方法,并为新的竹笋功能性食品和食品添加剂的研发提供基础。展开更多
文摘为提高燃料空气炸弹(Fuel Air Explosive,FAE)装置爆炸抛撒燃料的极限速度并使速度更加平均,在不改变现有装置整体结构的情况下,采用数值模拟的方法研究起爆方式对FAE装置燃料抛撒径向极限速度的影响。使用有限元分析软件的任意拉格朗日-欧拉算法对圆台型FAE装置抛撒燃料进行数值模拟,对比单点起爆、多点起爆和近似线起爆情况下相同位置节点的径向抛撒速度变化情况。研究结果表明,对于燃料上的单元而言,距离较近的起爆点设置会对这个单元上燃料的抛撒运动产生抑制效果,近似线起爆的方式可以使云雾抛撒得更加均匀,为FAE爆炸燃料抛撒数值模拟的进一步细化研究奠定了基础。
基金National Administration of Traditional Chinese Medicine Evidence-Based Capacity Building Project(2019XZZXXH005)Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province(2022ZY2022)+1 种基金Henan Provincial Top Talents Cultivation Project in Traditional Chinese Medicine Discipline of Henan Provincial Traditional Chinese Medicine Inheritance and Innovation Talents Project(Zhongjing Project)(Henan Health TraditionalMedicine Letter[2021]No.15)Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province(2023ZY2062).
文摘Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.
文摘以雷笋膳食纤维为研究对象,经纤维素酶和木聚糖酶改性处理,分析其理化性能和结构特征变化。持水力、持油力、膨胀力和吸附能力(亚硝酸盐和胆固醇)为膳食纤维(dietary fiber,DF)理化性能的考察指标,通过扫描电子显微镜(SEM)、傅里叶红外光谱(FT-IR)和X-射线衍射(XRD)检测膳食纤维的结构变化。结果表明,酶法改性后,可溶性膳食纤维含量从(1.02±0.04) g/100 g DF增加至(6.80±0.15) g/100 g DF; DF的持水量,持油量和膨胀能力、吸附胆固醇和亚硝酸根离子能力均显著增加(P<0.05)。改性DF的表面孔隙增加、比表面积增大,木质素和纤维素部分降解,结晶度降低。因此,使用纤维素酶和木聚糖酶是一种优良的雷笋DF酶法改性方法,并为新的竹笋功能性食品和食品添加剂的研发提供基础。
