Benflumetol was reported as a new antimalarial drug by professor Ron-xian Deng et al. The drug was awarded a first prize of National invention in 1990 for it’s new structure, high effect for The treatment of pernicio...Benflumetol was reported as a new antimalarial drug by professor Ron-xian Deng et al. The drug was awarded a first prize of National invention in 1990 for it’s new structure, high effect for The treatment of pernicious malaria and low side reaction and so on. In this paper MS and LC-ESI-MS were applied to identify The plasma drug and drug’s urine excreta of several male health volunteers after The drug oral administration.展开更多
Amoxicillin is a kind of β-lactam antibacterial.It has been widely used in clinic.Recently,some products of amoxicillin were found to be unqualified in content and acidity.In this paper,the quality of amoxicillin wer...Amoxicillin is a kind of β-lactam antibacterial.It has been widely used in clinic.Recently,some products of amoxicillin were found to be unqualified in content and acidity.In this paper,the quality of amoxicillin were firstly analyzed by using FT-ICR-MS and FT-ICR-MS/MS method by comparing the accurate relative molecular mass of amoxicillin fragmentation and its accurate mass obtained.展开更多
Three methods to determine The molecular weight of a protein electroblotted onto PVDF or NC membrane have been investigated in this paper The "Pseudo-dissolution Method"(direct method) is able to directly an...Three methods to determine The molecular weight of a protein electroblotted onto PVDF or NC membrane have been investigated in this paper The "Pseudo-dissolution Method"(direct method) is able to directly analyze proteins on membrane provided a good staining-destaining process and a gentle transferring strategy were carried out. The "Extraction Method" is suitable for various kinds of membranes, its reproducibility, sensitivity, and resolution are high. The"Dissolution-Precipitation Method" is the best among these methods. The quality of MALDI-TOF spectrum using this simple method is the same as The routine strategy of MALDI.展开更多
In order to explore the effect of electroacupuncture on rats with acute spinal injury,we established animal model of the spinal injury.Total proteins were extracted from spinal cord of normal rats,acute spinal injury ...In order to explore the effect of electroacupuncture on rats with acute spinal injury,we established animal model of the spinal injury.Total proteins were extracted from spinal cord of normal rats,acute spinal injury rats and acute spinal injury rat treated by electroacupuncture,and separated by 2-DE.10 differential expressed proteins were identified by the MALDI-TOF-TOF-MS with high mass accuracy,high mascot scores and high reliability.展开更多
文摘Benflumetol was reported as a new antimalarial drug by professor Ron-xian Deng et al. The drug was awarded a first prize of National invention in 1990 for it’s new structure, high effect for The treatment of pernicious malaria and low side reaction and so on. In this paper MS and LC-ESI-MS were applied to identify The plasma drug and drug’s urine excreta of several male health volunteers after The drug oral administration.
文摘Amoxicillin is a kind of β-lactam antibacterial.It has been widely used in clinic.Recently,some products of amoxicillin were found to be unqualified in content and acidity.In this paper,the quality of amoxicillin were firstly analyzed by using FT-ICR-MS and FT-ICR-MS/MS method by comparing the accurate relative molecular mass of amoxicillin fragmentation and its accurate mass obtained.
文摘Three methods to determine The molecular weight of a protein electroblotted onto PVDF or NC membrane have been investigated in this paper The "Pseudo-dissolution Method"(direct method) is able to directly analyze proteins on membrane provided a good staining-destaining process and a gentle transferring strategy were carried out. The "Extraction Method" is suitable for various kinds of membranes, its reproducibility, sensitivity, and resolution are high. The"Dissolution-Precipitation Method" is the best among these methods. The quality of MALDI-TOF spectrum using this simple method is the same as The routine strategy of MALDI.
文摘In order to explore the effect of electroacupuncture on rats with acute spinal injury,we established animal model of the spinal injury.Total proteins were extracted from spinal cord of normal rats,acute spinal injury rats and acute spinal injury rat treated by electroacupuncture,and separated by 2-DE.10 differential expressed proteins were identified by the MALDI-TOF-TOF-MS with high mass accuracy,high mascot scores and high reliability.
