目的探讨经皮冠状动脉介入(PCI)对高龄冠心病患者生活质量的影响。方法行PCI治疗高龄冠心病患者(年龄≥80岁)64例(PCI治疗组),选择同期具有PCI适应证,但因冠状动脉病变复杂、合并其他疾病、有抗凝禁忌证、经济原因或本人意愿等原因而未...目的探讨经皮冠状动脉介入(PCI)对高龄冠心病患者生活质量的影响。方法行PCI治疗高龄冠心病患者(年龄≥80岁)64例(PCI治疗组),选择同期具有PCI适应证,但因冠状动脉病变复杂、合并其他疾病、有抗凝禁忌证、经济原因或本人意愿等原因而未行PCI高龄冠心病患者93例(单纯药物组)作为对照。出院时、出院后90 d采用中文版简明健康状况调查表(SF-36)评定患者生活质量。结果两组患者性别、年龄、糖尿病患病率、ST段抬高型心肌梗死比例比较,差异有统计学意义(P<0.05);其他基础临床资料比较,差异无统计学意义(P>0.05)。统计分析结果显示,用多元协方差分析控制基础临床资料的差异后,出院后90 d PCI治疗组的SF-36总得分及生理职能、躯体疼痛、健康状况得分改善情况优于单纯药物组(P<0.05)。结论 PCI治疗能改善高龄冠心病患者的生活质量。展开更多
Background Coronary microembolization （CME） is characterized by distal microvascular occlusion. However, the inflammatory mechanisms and therapeutic targets of CME are largely unknown. Methods A total of 11 Guangxi ...Background Coronary microembolization （CME） is characterized by distal microvascular occlusion. However, the inflammatory mechanisms and therapeutic targets of CME are largely unknown. Methods A total of 11 Guangxi Bama miniature swines were divided into two groups： sham （n = 5） and CME （n = 6）. Microspheres were injected into the left anterior descending artery of the CME group to make an animal model of CME. The expres- sions of microRNA-146a （miR-146a） and IRAK1, TRAF6, and AUF1 in the myocardium were detected by qPCR. Results In the CME group, microspheres, microinfarction, and inflammatory cell infiltration were found under an optical microscope. The expression levels of miR-146a were low in both groups. After CME, the expression levels of IRAK1, TRAF6, and AUF1 in the CME group were upregulated compared with those in the sham group （P 〈 0.01;P 〈 0.05;P 〈 0.05, respectively）. Conclusions AUF1, IRAK1 and TRAF6, but not miR-146a, could be involved, in myocardium inflammation following CME.展开更多
文摘目的探讨经皮冠状动脉介入(PCI)对高龄冠心病患者生活质量的影响。方法行PCI治疗高龄冠心病患者(年龄≥80岁)64例(PCI治疗组),选择同期具有PCI适应证,但因冠状动脉病变复杂、合并其他疾病、有抗凝禁忌证、经济原因或本人意愿等原因而未行PCI高龄冠心病患者93例(单纯药物组)作为对照。出院时、出院后90 d采用中文版简明健康状况调查表(SF-36)评定患者生活质量。结果两组患者性别、年龄、糖尿病患病率、ST段抬高型心肌梗死比例比较,差异有统计学意义(P<0.05);其他基础临床资料比较,差异无统计学意义(P>0.05)。统计分析结果显示,用多元协方差分析控制基础临床资料的差异后,出院后90 d PCI治疗组的SF-36总得分及生理职能、躯体疼痛、健康状况得分改善情况优于单纯药物组(P<0.05)。结论 PCI治疗能改善高龄冠心病患者的生活质量。
基金supported by Guangxi Province Medical Technology Research and Development Project(Grant No.S201303_01)Youth Science Foundation of Guangxi Medical University(No.GXMUYSF201213)
文摘Background Coronary microembolization （CME） is characterized by distal microvascular occlusion. However, the inflammatory mechanisms and therapeutic targets of CME are largely unknown. Methods A total of 11 Guangxi Bama miniature swines were divided into two groups： sham （n = 5） and CME （n = 6）. Microspheres were injected into the left anterior descending artery of the CME group to make an animal model of CME. The expres- sions of microRNA-146a （miR-146a） and IRAK1, TRAF6, and AUF1 in the myocardium were detected by qPCR. Results In the CME group, microspheres, microinfarction, and inflammatory cell infiltration were found under an optical microscope. The expression levels of miR-146a were low in both groups. After CME, the expression levels of IRAK1, TRAF6, and AUF1 in the CME group were upregulated compared with those in the sham group （P 〈 0.01;P 〈 0.05;P 〈 0.05, respectively）. Conclusions AUF1, IRAK1 and TRAF6, but not miR-146a, could be involved, in myocardium inflammation following CME.
