(+)-(S)-Angustureine was synthesized using a CuI-catalyzed coupling reaction of iodobenzene with an enan-tiopure -amino ester as the key step. The overall yield is 36% in 7 linear steps.
基金the National Natural Science Foundation of China (Nos. 20321202,20132030).
文摘(+)-(S)-Angustureine was synthesized using a CuI-catalyzed coupling reaction of iodobenzene with an enan-tiopure -amino ester as the key step. The overall yield is 36% in 7 linear steps.