Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation.In this study,we measured the serum levels of inflammatory factors ...Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation.In this study,we measured the serum levels of inflammatory factors and evaluated the correlations of postoperative sleep efficiency with C-reactive protein and interleukin-6(IL-6)in IE patients.Methods A total of 117 post-operative patients with IE were enrolled in the study.All patients were tested using a wearable actigraphy device for their sleep efficiency.All patients were examined for C-reactive protein,and 72 patients were tested for IL-6.Results A correlation analysis was performed between C-reactive protein and IL-6.The average sleep efficiency of most of the IE patients was 80.81±8.52%,and the average result of the C-reactive protein test was 29.98±26.3mg/L.The correlation coefficient between sleep efficiency and C-reactive protein was-0.3011.The average result of the IL-6 test was 24.52±23.85 pg/mL,and the correlation coefficient between sleep efficiency and IL-6 was-0.3543.Conclusions Postoperative sleep efficiency is negatively correlated with serum levels of C-reactiveprotein and IL-6 in patients with IE.展开更多
基金supported by Science and Technology Planning Project of Guangdong Province(No.A2016057/B2015093)
文摘Background Sleep disorders have been found in patients with infective endocarditis(IE)and are reported to have a strong correlation with inflammation.In this study,we measured the serum levels of inflammatory factors and evaluated the correlations of postoperative sleep efficiency with C-reactive protein and interleukin-6(IL-6)in IE patients.Methods A total of 117 post-operative patients with IE were enrolled in the study.All patients were tested using a wearable actigraphy device for their sleep efficiency.All patients were examined for C-reactive protein,and 72 patients were tested for IL-6.Results A correlation analysis was performed between C-reactive protein and IL-6.The average sleep efficiency of most of the IE patients was 80.81±8.52%,and the average result of the C-reactive protein test was 29.98±26.3mg/L.The correlation coefficient between sleep efficiency and C-reactive protein was-0.3011.The average result of the IL-6 test was 24.52±23.85 pg/mL,and the correlation coefficient between sleep efficiency and IL-6 was-0.3543.Conclusions Postoperative sleep efficiency is negatively correlated with serum levels of C-reactiveprotein and IL-6 in patients with IE.