The facile enantioselective synthesis of the di-O-methyl ethers of (-)-agatharesinol (1b), (-)-sugiresionl (2b), (+)-nyasol (3b) and (+)-tetrahydronyasol (4) were achieved in high yield. The absolute...The facile enantioselective synthesis of the di-O-methyl ethers of (-)-agatharesinol (1b), (-)-sugiresionl (2b), (+)-nyasol (3b) and (+)-tetrahydronyasol (4) were achieved in high yield. The absolute configuration of (+)-3a was confirmed via first total synthesis of (+)-3b and (+)-4.展开更多
A convenient and rapid approach for the syntheses of (-)-kaerophyllin (1),(-)-hinokinin (2) and (±)-isohinokinin (3) was described. The key steps were involved in condensation of aromatic aldehyde and alkylation ...A convenient and rapid approach for the syntheses of (-)-kaerophyllin (1),(-)-hinokinin (2) and (±)-isohinokinin (3) was described. The key steps were involved in condensation of aromatic aldehyde and alkylation of the resulting ester to give the complete skeleton of dibenzylbutyrolactone-lignan. Hydrolysis,followed by resolution with quinine,reduction and when appropriate,oxidation gave the title compound. The asymmetric total synthesis of the kaerophyllin (1) was reported for the first time.展开更多
基金Projet supported by-the-Speei-al Doctorial Program Funds of the Ministry of Education of China (No. 20040730008), Gansu Science Foundation (No. 3ZS051-A25-004).
文摘The facile enantioselective synthesis of the di-O-methyl ethers of (-)-agatharesinol (1b), (-)-sugiresionl (2b), (+)-nyasol (3b) and (+)-tetrahydronyasol (4) were achieved in high yield. The absolute configuration of (+)-3a was confirmed via first total synthesis of (+)-3b and (+)-4.
文摘A convenient and rapid approach for the syntheses of (-)-kaerophyllin (1),(-)-hinokinin (2) and (±)-isohinokinin (3) was described. The key steps were involved in condensation of aromatic aldehyde and alkylation of the resulting ester to give the complete skeleton of dibenzylbutyrolactone-lignan. Hydrolysis,followed by resolution with quinine,reduction and when appropriate,oxidation gave the title compound. The asymmetric total synthesis of the kaerophyllin (1) was reported for the first time.