Background Sleep apnea（SA） is a common disorder in general population, especially cardiovascular disease （CVD） patients. However, its role in cardiomyopathy etiology is still unclear. Methods In this single-center...Background Sleep apnea（SA） is a common disorder in general population, especially cardiovascular disease （CVD） patients. However, its role in cardiomyopathy etiology is still unclear. Methods In this single-center observational study, we enrolled 2740 CVD patients consecutively from 2013 to 2016. Among study subjects, 65 were diagnosed as idiopathic dilated cardiomyopathy（DCM） and 34 were hypertrophic cardiomyopathy（HCM）. Patients underwent sleep study with portable monitoring devices and diagnosed as non-SA （AHI〈5）, mild （5-≤ AHI≤15）, moderate （15〈AHI≤30） or severe SA （AHI〉30） using the apnea-hypopnea index （AHI）. Central sleep apnea（CSA） and obstructive sleep apnea（OSA） were defined by central event percentage, with 50% as cut-value. Results The prevalence of SA was higher in DCM patients. While the prevalence of moderate to severe SA was similar in HCM and other CVD patients （32.4% vs. 34.3%, P 〉0.1）, it was significantly higher in DCM patients （49.2%, P =0.017 vs. other CVD patients）. The prevalence of CSA in DCM patients was also higher than other CVD patients （9.2% vs. 3.2%, P〈0.01）, but the difference of OSA was not statistically significant （40.0% vs. 30.3%, P =0.229）. In comparison to other heart failure with reduced ejection fraction （HFrEF） patients, the result was nearly at the same level. Conclusions SA is more common in idiopathic dilated cardiomyopathy patients. Prevalence of moderate to severe SA and CSA is higher in idiopathic HCM patients than other CVD and HFrEF patients.展开更多
Background Previous studies have suggested an association between obstructive sleep apnea(OSA) and left ventricular(LV) remodeling, but it remains unclear whether there's a specific remodeling pattern related to t...Background Previous studies have suggested an association between obstructive sleep apnea(OSA) and left ventricular(LV) remodeling, but it remains unclear whether there's a specific remodeling pattern related to the OSA. Methods This study was a cross-sectional study of 1377 cardiovascular disease(CVD) patients. Respiratory events during sleep were recorded by portable monitors and apnea hypopnea index(AHI) was used to quantify OSA severity. Echocardiography was used to assess left ventricular structure. The left ventricular geometry was divided into four groups according to left ventricular mass index(LVMI) and relative wall thickness(RWT):normal geometry, concentric remodeling, concentric hypertrophy and eccentric hypertrophy. Results The prevalence of OSA was significantly higher in patients with abnormal left ventricular geometry(75.2% vs. 68.9%, P=0.012). Compared to patients with AHI < 5, those with AHI ≥ 30 had an odds ratio of 1.53(95%CI: 1.03-2.28)for LV hypertrophy in male patients, after adjustment for age, body mass index, hypertension, diabetes, coronary artery disease and metabolism syndrome. Furthermore, after adjustment for confounding factor, severe OSA(compared with non-OSA) was significantly associated with the increased risk of eccentric hypertrophy in men(OR: 2.34, 95%CI: 1.23-4.44). No association was observed between OSA and other types of LV remodeling in neither men or women. Conclusions OSA is implicated in LV remodeling and severe OSA is independently associated with a higher risk of eccentric LV hypertrophy in male patients[.S Chin J Cardiol 2019;20(1):1-9]展开更多
基金supported by Science and Technology Planning Project of Guangdong Province(No.2014A020212637)
文摘Background Sleep apnea（SA） is a common disorder in general population, especially cardiovascular disease （CVD） patients. However, its role in cardiomyopathy etiology is still unclear. Methods In this single-center observational study, we enrolled 2740 CVD patients consecutively from 2013 to 2016. Among study subjects, 65 were diagnosed as idiopathic dilated cardiomyopathy（DCM） and 34 were hypertrophic cardiomyopathy（HCM）. Patients underwent sleep study with portable monitoring devices and diagnosed as non-SA （AHI〈5）, mild （5-≤ AHI≤15）, moderate （15〈AHI≤30） or severe SA （AHI〉30） using the apnea-hypopnea index （AHI）. Central sleep apnea（CSA） and obstructive sleep apnea（OSA） were defined by central event percentage, with 50% as cut-value. Results The prevalence of SA was higher in DCM patients. While the prevalence of moderate to severe SA was similar in HCM and other CVD patients （32.4% vs. 34.3%, P 〉0.1）, it was significantly higher in DCM patients （49.2%, P =0.017 vs. other CVD patients）. The prevalence of CSA in DCM patients was also higher than other CVD patients （9.2% vs. 3.2%, P〈0.01）, but the difference of OSA was not statistically significant （40.0% vs. 30.3%, P =0.229）. In comparison to other heart failure with reduced ejection fraction （HFrEF） patients, the result was nearly at the same level. Conclusions SA is more common in idiopathic dilated cardiomyopathy patients. Prevalence of moderate to severe SA and CSA is higher in idiopathic HCM patients than other CVD and HFrEF patients.
文摘Background Previous studies have suggested an association between obstructive sleep apnea(OSA) and left ventricular(LV) remodeling, but it remains unclear whether there's a specific remodeling pattern related to the OSA. Methods This study was a cross-sectional study of 1377 cardiovascular disease(CVD) patients. Respiratory events during sleep were recorded by portable monitors and apnea hypopnea index(AHI) was used to quantify OSA severity. Echocardiography was used to assess left ventricular structure. The left ventricular geometry was divided into four groups according to left ventricular mass index(LVMI) and relative wall thickness(RWT):normal geometry, concentric remodeling, concentric hypertrophy and eccentric hypertrophy. Results The prevalence of OSA was significantly higher in patients with abnormal left ventricular geometry(75.2% vs. 68.9%, P=0.012). Compared to patients with AHI < 5, those with AHI ≥ 30 had an odds ratio of 1.53(95%CI: 1.03-2.28)for LV hypertrophy in male patients, after adjustment for age, body mass index, hypertension, diabetes, coronary artery disease and metabolism syndrome. Furthermore, after adjustment for confounding factor, severe OSA(compared with non-OSA) was significantly associated with the increased risk of eccentric hypertrophy in men(OR: 2.34, 95%CI: 1.23-4.44). No association was observed between OSA and other types of LV remodeling in neither men or women. Conclusions OSA is implicated in LV remodeling and severe OSA is independently associated with a higher risk of eccentric LV hypertrophy in male patients[.S Chin J Cardiol 2019;20(1):1-9]
