Melanoma,a type of skin malignancy with a high incidence and poor prognosis,is a global public health issue.The tumorigenesis and pathogenesis of melanoma involve genetic mutations,metabolic disruption,and immune evas...Melanoma,a type of skin malignancy with a high incidence and poor prognosis,is a global public health issue.The tumorigenesis and pathogenesis of melanoma involve genetic mutations,metabolic disruption,and immune evasion.Tumors undergo immune editing to escape immune surveillance,and immune escape has been identified as a critical factor in the development and progression of melanoma.展开更多
基金supported by the National Key Research and Development Program of China(2019YFE0120800 and 2019YFA0111600)the National Natural Science Foundation of China for Innovative Research Group Project(82221002,82130090,81874242,31800979,and 82073145)+2 种基金the Natural Science Foundation of China for Outstanding Young Scholars(82022060)the Natural Science Foundation of Hunan Province for Outstanding Young Scholars(2019JJ30040)Talent Young Scholars of Hunan Province(2019RS2009)。
文摘Melanoma,a type of skin malignancy with a high incidence and poor prognosis,is a global public health issue.The tumorigenesis and pathogenesis of melanoma involve genetic mutations,metabolic disruption,and immune evasion.Tumors undergo immune editing to escape immune surveillance,and immune escape has been identified as a critical factor in the development and progression of melanoma.