Arginine vasopressin (AVP) is an endogenous neuropeptide that has been reported to enhance the acquisition of active avoidance behavior in mice and light-dark discrimination learning in rats. In addition, our previous...Arginine vasopressin (AVP) is an endogenous neuropeptide that has been reported to enhance the acquisition of active avoidance behavior in mice and light-dark discrimination learning in rats. In addition, our previous work reported the modulating effect of AVP on hippocampal neuronal activity. Thus, it was suggested that hippocampus may be one of the CNS sites mediating the enhancing effect of AVP on acquisition. As we know, the fimbria-fornix is the main afferent and efferent pathways of hippocampus. Accordingly,展开更多
Although the enhancing effect of vasopressin on learning and memory has been re-ported by quite a lot of authors, its mechanisms still remain unclear at present. Somereports showed that the central sites of its enhanc...Although the enhancing effect of vasopressin on learning and memory has been re-ported by quite a lot of authors, its mechanisms still remain unclear at present. Somereports showed that the central sites of its enhancing effect are mainly located inlimbic-midbrain structures, inculding hippocampus, septal nucleus, amygdala and raphe nu-cleus, and through these structures AVP exerts its modulatory effect on learning and mem-ory processes. In order to clarify the mechanisms of enhancing effect of 8-arginine-vasopressin (AVP) on discrimination learning in rats, especially the role of endogenousAVP in it, the method of intracerebral microcijection of anti-AVP serum was used in thepresent work.展开更多
基金Project supported by the National Natural Science Foundation of China and Science Fund of Chinese Academy of Sciences.
文摘Arginine vasopressin (AVP) is an endogenous neuropeptide that has been reported to enhance the acquisition of active avoidance behavior in mice and light-dark discrimination learning in rats. In addition, our previous work reported the modulating effect of AVP on hippocampal neuronal activity. Thus, it was suggested that hippocampus may be one of the CNS sites mediating the enhancing effect of AVP on acquisition. As we know, the fimbria-fornix is the main afferent and efferent pathways of hippocampus. Accordingly,
文摘Although the enhancing effect of vasopressin on learning and memory has been re-ported by quite a lot of authors, its mechanisms still remain unclear at present. Somereports showed that the central sites of its enhancing effect are mainly located inlimbic-midbrain structures, inculding hippocampus, septal nucleus, amygdala and raphe nu-cleus, and through these structures AVP exerts its modulatory effect on learning and mem-ory processes. In order to clarify the mechanisms of enhancing effect of 8-arginine-vasopressin (AVP) on discrimination learning in rats, especially the role of endogenousAVP in it, the method of intracerebral microcijection of anti-AVP serum was used in thepresent work.
