目的探讨酮咯酸氨丁三醇对重型颅脑损伤患者行深静脉穿刺置管静脉血栓发生的预防作用和护理体会。方法对重型颅脑损伤患者分别单纯行深静脉穿刺置管(对照组)和深静脉穿刺置管加用酮咯酸氨丁三醇(观察组),配合相关护理措施,采用放射免疫...目的探讨酮咯酸氨丁三醇对重型颅脑损伤患者行深静脉穿刺置管静脉血栓发生的预防作用和护理体会。方法对重型颅脑损伤患者分别单纯行深静脉穿刺置管(对照组)和深静脉穿刺置管加用酮咯酸氨丁三醇(观察组),配合相关护理措施,采用放射免疫分析法和发射底物分析法测定在行深静脉穿刺前及深静脉穿刺后1h及1、2、3 d 5个不同时间段镇痛血浆β-内啡肽(β-EP)、血栓素A2(TXA2)、6-酮-前列腺素F1α(6-keto-PGF1α)、血浆组织型纤溶酶原激活物(tPA)和血纤溶酶原激活抑制物(PAI)含量的变化。结果对照组置管前β-EP、TXA2和PAI随时间进展呈递增趋势,6-keto-PGF1α和tPA则呈递减趋势;观察组则与之相反。结论酮咯酸氨丁三醇通过减少疼痛应激,触发纤溶系统和抑制血小板聚集,稳定正常人体内凝血系统与抗凝血系统的动态平衡,同时配合优质的护理,可减少静脉血栓的发生。展开更多
Objective： To evaluate the efficacy of transcutaneous electroacupoint stimulation with a train-of-four （TOF） mode for the prevention of postoperative nausea and vomiting （PONV） in the patients undergoing laparosc...Objective： To evaluate the efficacy of transcutaneous electroacupoint stimulation with a train-of-four （TOF） mode for the prevention of postoperative nausea and vomiting （PONV） in the patients undergoing laparoscopic cholecystectomy. Methods： Ninety-six ASA Grade Ⅰ-Ⅱ patients scheduled for laparoscopic cholecystectomy were randomized into Neiguan （P6） electroacupoint stimulation group （treated group） and a placebo control group （placement of electrodes without electroacupoint stimulation）. The anesthetic regimen was standardized by needling at Neiguan on the left side and connecting the TOF peripheral nerve stimulator. The incidence of nausea, vomiting, severity, antiemetic dosage and the degree of pain were assessed at 0, 60, 120 min, and 24 h after surgery. Results： The incidence of nausea and vomiting, the dose of antiemetics and the occurrence of severe nausea were all significantly lower in the treated group compared with the control group and the score for pain was obviously reduced in patients of the treated group at 24 h post-operation （P〈0.05 or P〈0.01）. Conclusion： Transcutaneous electroacupoint stimulation at P6 with the TOF mode could reduce the incidence and severity of nausea and vomiting with analgesic effects.展开更多
文摘目的探讨酮咯酸氨丁三醇对重型颅脑损伤患者行深静脉穿刺置管静脉血栓发生的预防作用和护理体会。方法对重型颅脑损伤患者分别单纯行深静脉穿刺置管(对照组)和深静脉穿刺置管加用酮咯酸氨丁三醇(观察组),配合相关护理措施,采用放射免疫分析法和发射底物分析法测定在行深静脉穿刺前及深静脉穿刺后1h及1、2、3 d 5个不同时间段镇痛血浆β-内啡肽(β-EP)、血栓素A2(TXA2)、6-酮-前列腺素F1α(6-keto-PGF1α)、血浆组织型纤溶酶原激活物(tPA)和血纤溶酶原激活抑制物(PAI)含量的变化。结果对照组置管前β-EP、TXA2和PAI随时间进展呈递增趋势,6-keto-PGF1α和tPA则呈递减趋势;观察组则与之相反。结论酮咯酸氨丁三醇通过减少疼痛应激,触发纤溶系统和抑制血小板聚集,稳定正常人体内凝血系统与抗凝血系统的动态平衡,同时配合优质的护理,可减少静脉血栓的发生。
文摘Objective： To evaluate the efficacy of transcutaneous electroacupoint stimulation with a train-of-four （TOF） mode for the prevention of postoperative nausea and vomiting （PONV） in the patients undergoing laparoscopic cholecystectomy. Methods： Ninety-six ASA Grade Ⅰ-Ⅱ patients scheduled for laparoscopic cholecystectomy were randomized into Neiguan （P6） electroacupoint stimulation group （treated group） and a placebo control group （placement of electrodes without electroacupoint stimulation）. The anesthetic regimen was standardized by needling at Neiguan on the left side and connecting the TOF peripheral nerve stimulator. The incidence of nausea, vomiting, severity, antiemetic dosage and the degree of pain were assessed at 0, 60, 120 min, and 24 h after surgery. Results： The incidence of nausea and vomiting, the dose of antiemetics and the occurrence of severe nausea were all significantly lower in the treated group compared with the control group and the score for pain was obviously reduced in patients of the treated group at 24 h post-operation （P〈0.05 or P〈0.01）. Conclusion： Transcutaneous electroacupoint stimulation at P6 with the TOF mode could reduce the incidence and severity of nausea and vomiting with analgesic effects.
