目的磁共振灌输成像持续监测局部进展期乳腺癌(locally advanced breast cancer,LABC)在新辅助化疗下的疗效价值评估。方法对33例局部乳腺癌患者行新辅助化疗后(手术前),根据疗效分为效应组与无效应组,对比两组癌灶退缩率(Tumor regress...目的磁共振灌输成像持续监测局部进展期乳腺癌(locally advanced breast cancer,LABC)在新辅助化疗下的疗效价值评估。方法对33例局部乳腺癌患者行新辅助化疗后(手术前),根据疗效分为效应组与无效应组,对比两组癌灶退缩率(Tumor regression rate,TRR)、最大信号衰减率(Maximum signal intensity loss rate,MSILR)以及肿瘤灶体积(Gross tumor volume,GTV)之间的关系。结果行化疗术后效应组实体瘤平均体积为(2.88±1.02)cm3,该数值低无效应组,且该差异具统计学意义(P<0.05);效应组治疗后的MSILR为(14±11.17)%,纵向对比低于效应组化疗前(41.51±3.5)%,横向对比低于无效组化疗后(42.6±4.8)%;效应组(14.64±5.42)与无效应组(7.86±3.17)患者间的灌注信号MSILR明显变化,且该差别统计学上有意义(P<0.05);MSILR的均值与TRR为正相关(r=0.320,P=0.53)。结论磁共振灌输加权成像(Perfusion weighted magnetic resonance imaging,PMRI)用于跟踪监测LABC新辅助化疗疗效的临床价值可以确认,但是否可作预后评估因子仍需要进一步大数据的检测和分析的支持。展开更多
To study the biopathological characteristics of the transitional mucosa adjacent to rectal carcinoma, 34 cases were subjected to mucin histochemical and immunohistochemical study to observe the expression of p53 and ...To study the biopathological characteristics of the transitional mucosa adjacent to rectal carcinoma, 34 cases were subjected to mucin histochemical and immunohistochemical study to observe the expression of p53 and p21 protein in distal mucosa adjacent to rectal carcinoma and its relationship to the mucin change. The expression of p53 protein was found in 29. 4 % (10/34) of distal transitional mucosa in the cytoplasm of goblet cells, and its positive staining was within 4 cm from carcinoma margin. A11 p53 positive mucosa was transitional mucosa. Overexpression of p21 protein was found in 26.5 % (9/34) of distal transitional mucosa in cytoplasm of crypt cells, and its positive staining was within 2 cm from carcinoma margin. There was no relationship between the expression of p53 and p21 protein in carcinoma and that in transitional mucosa ( P >0.05). These findings indicated that there was aberrant alteration of p53 and p21 genes in transitional mucosa adjacent to colorectal carcinoma, which provided further evidence that transitional mucosa was an unstable pre cancerous change. The aberrant mucin change and genetic alteration in distal mucosa of rectal cancer is within 4 cm.展开更多
文摘目的磁共振灌输成像持续监测局部进展期乳腺癌(locally advanced breast cancer,LABC)在新辅助化疗下的疗效价值评估。方法对33例局部乳腺癌患者行新辅助化疗后(手术前),根据疗效分为效应组与无效应组,对比两组癌灶退缩率(Tumor regression rate,TRR)、最大信号衰减率(Maximum signal intensity loss rate,MSILR)以及肿瘤灶体积(Gross tumor volume,GTV)之间的关系。结果行化疗术后效应组实体瘤平均体积为(2.88±1.02)cm3,该数值低无效应组,且该差异具统计学意义(P<0.05);效应组治疗后的MSILR为(14±11.17)%,纵向对比低于效应组化疗前(41.51±3.5)%,横向对比低于无效组化疗后(42.6±4.8)%;效应组(14.64±5.42)与无效应组(7.86±3.17)患者间的灌注信号MSILR明显变化,且该差别统计学上有意义(P<0.05);MSILR的均值与TRR为正相关(r=0.320,P=0.53)。结论磁共振灌输加权成像(Perfusion weighted magnetic resonance imaging,PMRI)用于跟踪监测LABC新辅助化疗疗效的临床价值可以确认,但是否可作预后评估因子仍需要进一步大数据的检测和分析的支持。
文摘To study the biopathological characteristics of the transitional mucosa adjacent to rectal carcinoma, 34 cases were subjected to mucin histochemical and immunohistochemical study to observe the expression of p53 and p21 protein in distal mucosa adjacent to rectal carcinoma and its relationship to the mucin change. The expression of p53 protein was found in 29. 4 % (10/34) of distal transitional mucosa in the cytoplasm of goblet cells, and its positive staining was within 4 cm from carcinoma margin. A11 p53 positive mucosa was transitional mucosa. Overexpression of p21 protein was found in 26.5 % (9/34) of distal transitional mucosa in cytoplasm of crypt cells, and its positive staining was within 2 cm from carcinoma margin. There was no relationship between the expression of p53 and p21 protein in carcinoma and that in transitional mucosa ( P >0.05). These findings indicated that there was aberrant alteration of p53 and p21 genes in transitional mucosa adjacent to colorectal carcinoma, which provided further evidence that transitional mucosa was an unstable pre cancerous change. The aberrant mucin change and genetic alteration in distal mucosa of rectal cancer is within 4 cm.
