目的系统评价针刺治疗功能性肠病(FBD)的神经影像学研究,探讨针刺治疗FBD的中枢机制。方法系统检索中国知网、万方、Web of Science、Embase、PubMed 5个数据库,筛选纳入基于神经影像技术的针刺治疗FBD临床研究,分析总结研究设计,整理...目的系统评价针刺治疗功能性肠病(FBD)的神经影像学研究,探讨针刺治疗FBD的中枢机制。方法系统检索中国知网、万方、Web of Science、Embase、PubMed 5个数据库,筛选纳入基于神经影像技术的针刺治疗FBD临床研究,分析总结研究设计,整理针刺干预对FBD患者脑功能活动模式的影响。结果共筛选304篇,纳入9篇文献,这些研究从即时影响和长期效应两个方面探讨了针刺治疗FBD的中枢机制,发现单次针刺显著影响了FBD患者扣带回、丘脑等区域功能活动,疗程针刺治疗显著调节了FBD患者前扣带回、脑岛、海马等区域的功能活动及连接模式。结论针刺可能通过调节FBD患者前扣带回、脑岛、丘脑等区域的功能活动及连接模式实现治疗作用。展开更多
Background:Reinforcing-reducing manipulations are a crucial part of acupuncture therapy.The reinforcing manipulation with heat sensation(RMHS) and the reducing manipulation by inducing cool sensation(RMCS) are two rep...Background:Reinforcing-reducing manipulations are a crucial part of acupuncture therapy.The reinforcing manipulation with heat sensation(RMHS) and the reducing manipulation by inducing cool sensation(RMCS) are two representative methods of reinforcing-reducing manipulations.This trial aims to investigate the characteristic of cerebral responses to these two typical acupuncture manipulations.Methods:A total of 35 healthy participants will be included and receive acupuncture stimulation with RMHS and RMCS in a random order.The psychology,cognition,and body constitution of participants will be measured by the Self-rating Anxiety Scale(SAS),the Self-rating Depression Scale(SDS),the mindful attention awareness scale(MAAS),the Constitution in Chinese Medicine Questionnaire(CCMQ),and the needle sensation will be evaluated after each acupuncture stimulation immediately.The cerebral activity changes elicited by RMHS and RMCS will be detected by functional near-infrared spectroscopy(fNIRS)and analyzed with the general linear model-based activation and the channel-to-channel functional connectivity.Discussion:This trial will investigate the cerebral response induced by RMHS and RMCS by real-time fNIRS,so as to map the characteristics of the central responses’ patterns to these two manipulations and preliminarily explore the mechanism of traditional acupuncture manipulations.展开更多
文摘目的系统评价针刺治疗功能性肠病(FBD)的神经影像学研究,探讨针刺治疗FBD的中枢机制。方法系统检索中国知网、万方、Web of Science、Embase、PubMed 5个数据库,筛选纳入基于神经影像技术的针刺治疗FBD临床研究,分析总结研究设计,整理针刺干预对FBD患者脑功能活动模式的影响。结果共筛选304篇,纳入9篇文献,这些研究从即时影响和长期效应两个方面探讨了针刺治疗FBD的中枢机制,发现单次针刺显著影响了FBD患者扣带回、丘脑等区域功能活动,疗程针刺治疗显著调节了FBD患者前扣带回、脑岛、海马等区域的功能活动及连接模式。结论针刺可能通过调节FBD患者前扣带回、脑岛、丘脑等区域的功能活动及连接模式实现治疗作用。
基金supported by grants from the National Natural Science Foundation of China (NO.81973960)the Sichuan Scientific and Technological Innovation Team (No.2019JDTD0011)。
文摘Background:Reinforcing-reducing manipulations are a crucial part of acupuncture therapy.The reinforcing manipulation with heat sensation(RMHS) and the reducing manipulation by inducing cool sensation(RMCS) are two representative methods of reinforcing-reducing manipulations.This trial aims to investigate the characteristic of cerebral responses to these two typical acupuncture manipulations.Methods:A total of 35 healthy participants will be included and receive acupuncture stimulation with RMHS and RMCS in a random order.The psychology,cognition,and body constitution of participants will be measured by the Self-rating Anxiety Scale(SAS),the Self-rating Depression Scale(SDS),the mindful attention awareness scale(MAAS),the Constitution in Chinese Medicine Questionnaire(CCMQ),and the needle sensation will be evaluated after each acupuncture stimulation immediately.The cerebral activity changes elicited by RMHS and RMCS will be detected by functional near-infrared spectroscopy(fNIRS)and analyzed with the general linear model-based activation and the channel-to-channel functional connectivity.Discussion:This trial will investigate the cerebral response induced by RMHS and RMCS by real-time fNIRS,so as to map the characteristics of the central responses’ patterns to these two manipulations and preliminarily explore the mechanism of traditional acupuncture manipulations.
