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子宫内膜异位症病灶离体内膜组织IL-6的分泌量研究 被引量:8
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作者 江 静 +3 位作者 王振海 吴瑞芳 修贺明 徐 铮 《生殖与避孕》 CAS CSCD 北大核心 2002年第1期30-32,39,共4页
目的:研究白细胞介素6(IL-6)在子宫内膜异位症(endometriosis,EM)发病中的作用。方法:采用酶联免疫吸附试验(ELISA)检测体外培养EM患者(12例)的异位内膜细胞和在位内膜细胞培养上清液中IL-6水平并与10例正常子宫内膜细胞作对照... 目的:研究白细胞介素6(IL-6)在子宫内膜异位症(endometriosis,EM)发病中的作用。方法:采用酶联免疫吸附试验(ELISA)检测体外培养EM患者(12例)的异位内膜细胞和在位内膜细胞培养上清液中IL-6水平并与10例正常子宫内膜细胞作对照;以及肿瘤坏死因子α(TNF-α)对异位内膜细胞分泌IL-6的影响。结果:三种内膜细胞培养上清液中IL-6水平明显不同。异位内膜细胞分泌的IL-6显著高于相应的在位内膜(P<0.01),而后者又明显高于正常子宫内膜(P<0.05),即IL-6分泌量异位内膜细胞>在位内膜细胞>正常子宫内膜细胞。TNF-α作用24h后可明显促进异位内膜细胞IL-6的分泌(P<0.01)。结论:异位内膜细胞可自主分泌高水平IL-6,TNF-α进一步诱导其分泌,与EM患者腹腔免疫和炎症反应相关。EM患者在位内膜细胞分泌IL-6的活性明显升高,可能导致其异位种植。 展开更多
关键词 子宫内膜异位症 细胞培养 白细胞介素6 肿瘤坏死因子α 酶联免疫吸附试验 子宫内膜细胞
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Global Response to Tropical Diabatic Heating Variability in Boreal Winter 被引量:1
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作者 张 旭 Hai LINt 江 静 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2012年第2期369-380,共12页
Global teleconnections associated with tropical convective activities were investigated, based on monthly data of 29 Northern Hemisphere winters: December, January, February, and March (DJFM). First, EOF analyses w... Global teleconnections associated with tropical convective activities were investigated, based on monthly data of 29 Northern Hemisphere winters: December, January, February, and March (DJFM). First, EOF analyses were performed on the outgoing longwave radiation (OLR) data to characterize the convective ac tivity variability in the tropical Indian Ocean and the western Pacific. The first EOF mode of the convective activity was highly correlated with the ENSO. The second EOF mode had an east–west dipole structure, and the third EOF mode had three convective activity centers. Two distinct teleconnection patterns were identified that were associated, respectively, with the second and third EOF modes. A global primitive equation model was used to investigate the physical mechanism that causes the global circulation anoma lies. The model responses to anomalous tropical thermal forcings that mimic the EOF patterns matched the general features of the observed circulation anomalies well, and they were mainly controlled by linear processes. The importance of convective activities in the tropical Indian Ocean and western Pacific to the extended and longrange forecasting capability in the extratropics is discussed. 展开更多
关键词 diabatic heating TELECONNECTION tropical convective activities
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