Chiral S,P-donor ferrocene-derived ligands were synthesized and applied in the asymmetric hydrogenation of quinolines using the [Ir(COD)Cl]2/S,P-ligand c omplex a s the catalyst in the presence of iodine. The effects ...Chiral S,P-donor ferrocene-derived ligands were synthesized and applied in the asymmetric hydrogenation of quinolines using the [Ir(COD)Cl]2/S,P-ligand c omplex a s the catalyst in the presence of iodine. The effects of the solvent and hydroge n pressure on conversion and enantioselectivity were examined, and up to 82% ee was obtained. The planar chirality plays an important role in this reaction. R- and S-enantiomers of 1,2,3,4-tetrahydroquinoline derivatives were ob tained using ligands 3 and 5, respectively.展开更多
文摘Chiral S,P-donor ferrocene-derived ligands were synthesized and applied in the asymmetric hydrogenation of quinolines using the [Ir(COD)Cl]2/S,P-ligand c omplex a s the catalyst in the presence of iodine. The effects of the solvent and hydroge n pressure on conversion and enantioselectivity were examined, and up to 82% ee was obtained. The planar chirality plays an important role in this reaction. R- and S-enantiomers of 1,2,3,4-tetrahydroquinoline derivatives were ob tained using ligands 3 and 5, respectively.
基金supported by the National Natural Science Foundation of China (21002022)the Chinese Ministry of Education (the Scientific Research Foundation for the Returned Overseas Chinese Scholars)~~
