目的：本研究旨在对比评价氯沙坦钾氢氯噻嗪片（海捷亚）和依那普利联合氢氯噻嗪治疗高龄高血压患者的疗效、安全性和耐受性。方法：72例高龄（〉80岁）的高血压患者,停用原有降压药物2周,收缩压150-190 mm Hg和舒张压90-120 mm Hg,被...目的：本研究旨在对比评价氯沙坦钾氢氯噻嗪片（海捷亚）和依那普利联合氢氯噻嗪治疗高龄高血压患者的疗效、安全性和耐受性。方法：72例高龄（〉80岁）的高血压患者,停用原有降压药物2周,收缩压150-190 mm Hg和舒张压90-120 mm Hg,被随机分为两组,治疗组每日口服氯沙坦钾氢氯噻嗪片（海捷亚）1片,对照组予依那普利和氢氯噻嗪每日各1片,治疗4周,观察用药期间血压、心率、肾功能、血糖、血脂、电解质及不良反应。结果：两组血压均有下降,治疗组有效率88.9%,对照组为75.0%,两组有效率比较差异有统计学意义（P〈0.05）,两组生化、心率指标治疗前后比较差异无统计学意义（P〉0.05）。结论：氯沙坦钾氢氯噻嗪片（海捷亚）对高龄患者降压效果肯定,安全性好,不良反应少,耐受性好。展开更多
The mechanical properties of formamidinium halide perovskites FABX_3(FA=CH(NH_2)_2; B=Pb, Sn; X=Br, I)are systematically investigated using first-principles calculations. Our results reveal that FABX_3 perovskites pos...The mechanical properties of formamidinium halide perovskites FABX_3(FA=CH(NH_2)_2; B=Pb, Sn; X=Br, I)are systematically investigated using first-principles calculations. Our results reveal that FABX_3 perovskites possess excellent mechanical flexibility, ductility and strong anisotropy. We shows that the planar organic cation FA+ has an important effect on the mechanical properties of FABX3 perovskites. In addition, our results indicate that (i) the moduli(bulk modulus B, Young's modulus E, and shear modulus G) of FABBr_3 are larger than those of FABI_3 for the same B atom, and (ii) the moduli of FAPbX_3 are larger than those of FASnX_3 for the same halide atom. The reason for the two trends is demonstrated by carefully analyzing the bond strength between B and X atoms based on the projected crystal orbital Hamilton population method.展开更多
Compared to AgNbO_(3) based ceramics, the experimental investigations on the single crystalline AgNbO_(3), especially the ground state and ferroic domain structures, are not on the same level. Here, based on successfu...Compared to AgNbO_(3) based ceramics, the experimental investigations on the single crystalline AgNbO_(3), especially the ground state and ferroic domain structures, are not on the same level. Here, based on successfully synthesized AgNbO_(3) single crystal using a flux method, we observed the coexistence of ferroelastic and ferroelectric domain structures by a combination study of polarized light microscopy and piezoresponse force microscopy.This finding may provide a new aspect for studying AgNbO_(3). The result also suggests a weak electromechanical response from the ferroelectric phase of AgNbO_(3), which is also supported by the transmission electron microscope characterization. Our results reveal that the AgNbO_(3) single crystal is in a polar ferroelectric phase at room temperature, clarifying its ground state which is controversial from the AgNbO_(3) ceramic materials.展开更多
文摘目的：本研究旨在对比评价氯沙坦钾氢氯噻嗪片（海捷亚）和依那普利联合氢氯噻嗪治疗高龄高血压患者的疗效、安全性和耐受性。方法：72例高龄（〉80岁）的高血压患者,停用原有降压药物2周,收缩压150-190 mm Hg和舒张压90-120 mm Hg,被随机分为两组,治疗组每日口服氯沙坦钾氢氯噻嗪片（海捷亚）1片,对照组予依那普利和氢氯噻嗪每日各1片,治疗4周,观察用药期间血压、心率、肾功能、血糖、血脂、电解质及不良反应。结果：两组血压均有下降,治疗组有效率88.9%,对照组为75.0%,两组有效率比较差异有统计学意义（P〈0.05）,两组生化、心率指标治疗前后比较差异无统计学意义（P〉0.05）。结论：氯沙坦钾氢氯噻嗪片（海捷亚）对高龄患者降压效果肯定,安全性好,不良反应少,耐受性好。
基金Supported by the National Natural Science Foundation of China under Grant No 11572040the Thousand Young Talents Program of Chinathe Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund(second phase)under Grant No U1501501
文摘The mechanical properties of formamidinium halide perovskites FABX_3(FA=CH(NH_2)_2; B=Pb, Sn; X=Br, I)are systematically investigated using first-principles calculations. Our results reveal that FABX_3 perovskites possess excellent mechanical flexibility, ductility and strong anisotropy. We shows that the planar organic cation FA+ has an important effect on the mechanical properties of FABX3 perovskites. In addition, our results indicate that (i) the moduli(bulk modulus B, Young's modulus E, and shear modulus G) of FABBr_3 are larger than those of FABI_3 for the same B atom, and (ii) the moduli of FAPbX_3 are larger than those of FASnX_3 for the same halide atom. The reason for the two trends is demonstrated by carefully analyzing the bond strength between B and X atoms based on the projected crystal orbital Hamilton population method.
基金Supported by the National Natural Science Foundation of China(Grant Nos.11572040,11604011 and 51972028)the National Key Research and Development Program of China(Grant No.2019YFA0307900)+1 种基金Beijing Natural Science Foundation(Grant No.Z190011)the Technological Innovation Project of Beijing Institute of technology。
文摘Compared to AgNbO_(3) based ceramics, the experimental investigations on the single crystalline AgNbO_(3), especially the ground state and ferroic domain structures, are not on the same level. Here, based on successfully synthesized AgNbO_(3) single crystal using a flux method, we observed the coexistence of ferroelastic and ferroelectric domain structures by a combination study of polarized light microscopy and piezoresponse force microscopy.This finding may provide a new aspect for studying AgNbO_(3). The result also suggests a weak electromechanical response from the ferroelectric phase of AgNbO_(3), which is also supported by the transmission electron microscope characterization. Our results reveal that the AgNbO_(3) single crystal is in a polar ferroelectric phase at room temperature, clarifying its ground state which is controversial from the AgNbO_(3) ceramic materials.
