目的 探讨血栓弹力图(thrombelastogram,TEG)与常规凝血功能指标、血小板计数(platelet count,PLT)的相关性。方法选取江西省肿瘤医院收治的107例患者为研究对象,每例研究对象均采集静脉血5.6 m L,其中1.8 m L加枸橼酸钠抗凝用于TEG检测...目的 探讨血栓弹力图(thrombelastogram,TEG)与常规凝血功能指标、血小板计数(platelet count,PLT)的相关性。方法选取江西省肿瘤医院收治的107例患者为研究对象,每例研究对象均采集静脉血5.6 m L,其中1.8 m L加枸橼酸钠抗凝用于TEG检测,1.8 m L加枸橼酸钠抗凝用于常规凝血功能检测,2.0 m L加乙二胺四乙酸二钾抗凝用于血常规检测。收集研究对象的反应时间(R值)、凝固时间(K值)、凝固角(α角)、血栓最大振幅(MA值)、凝血酶原时间(prot hrombin t ime,PT)、国际标准化比值(int ernat ional nor mali zed r at i o,INR)、活化部分凝血活酶时间(act i veat ed par t i al t hr omboplast i ng t i me,APTT)、纤维蛋白原(f i br i nogen,FBG)、PLT等指标。结果 R值与PT、INR、APTT呈正相关(P<0.01),与FBG、PLT相关性不显著,差异无统计学意义(P>0.05)。K值与PT、INR、APTT呈正相关(P<0.01),与FBG、PLT呈负相关(P<0.01)。α角与PT、INR、APTT呈负相关(P<0.05),与FBG、PLT呈正相关(P<0.01)。MA值与PT、INR、APTT呈负相关(P均<0.05),与FBG、PLT呈正相关(P均<0.01)。R值与K值呈正相关(P<0.01),与α角呈负相关(P<0.01),与MA值无相关性(P>0.05)。K值与α角、MA值均呈负相关(P均<0.01)。α角与MA值呈正相关(P<0.01)。结论 TEG与常规凝血功能指标、PLT有一定的相关性,但相关强度一般,因此TEG在临床上可以作为常规凝血功能、PLT的有效补充。展开更多
Chronic nephritis is a frequently seen disease,but difficult to treat,from which the restora-tion of damaged renal functions is even more dif-ficult.In clinical practice,the authors
The activity of superoxide dismutase(SOD) in renal cortex and erythrocytes, the level of lipid peroxidant(LPO)in plasma,renal function and morphology of leftover kidney were examined in rats.The results showed that H...The activity of superoxide dismutase(SOD) in renal cortex and erythrocytes, the level of lipid peroxidant(LPO)in plasma,renal function and morphology of leftover kidney were examined in rats.The results showed that Huangdan capsule could slow down the increase of BUN and Scr,promote the SOD activity in renal cortex and erythrocytes, reduce the level of LPO in plasma and delay the renal pathological changes in 5/6 nephrectomized rats.The mechanism of Huangdan capsule's antiperoxidant effect, its effect on the renal pathological changes and relationship between the two effects were also discussed.展开更多
文摘目的 探讨血栓弹力图(thrombelastogram,TEG)与常规凝血功能指标、血小板计数(platelet count,PLT)的相关性。方法选取江西省肿瘤医院收治的107例患者为研究对象,每例研究对象均采集静脉血5.6 m L,其中1.8 m L加枸橼酸钠抗凝用于TEG检测,1.8 m L加枸橼酸钠抗凝用于常规凝血功能检测,2.0 m L加乙二胺四乙酸二钾抗凝用于血常规检测。收集研究对象的反应时间(R值)、凝固时间(K值)、凝固角(α角)、血栓最大振幅(MA值)、凝血酶原时间(prot hrombin t ime,PT)、国际标准化比值(int ernat ional nor mali zed r at i o,INR)、活化部分凝血活酶时间(act i veat ed par t i al t hr omboplast i ng t i me,APTT)、纤维蛋白原(f i br i nogen,FBG)、PLT等指标。结果 R值与PT、INR、APTT呈正相关(P<0.01),与FBG、PLT相关性不显著,差异无统计学意义(P>0.05)。K值与PT、INR、APTT呈正相关(P<0.01),与FBG、PLT呈负相关(P<0.01)。α角与PT、INR、APTT呈负相关(P<0.05),与FBG、PLT呈正相关(P<0.01)。MA值与PT、INR、APTT呈负相关(P均<0.05),与FBG、PLT呈正相关(P均<0.01)。R值与K值呈正相关(P<0.01),与α角呈负相关(P<0.01),与MA值无相关性(P>0.05)。K值与α角、MA值均呈负相关(P均<0.01)。α角与MA值呈正相关(P<0.01)。结论 TEG与常规凝血功能指标、PLT有一定的相关性,但相关强度一般,因此TEG在临床上可以作为常规凝血功能、PLT的有效补充。
文摘Chronic nephritis is a frequently seen disease,but difficult to treat,from which the restora-tion of damaged renal functions is even more dif-ficult.In clinical practice,the authors
文摘The activity of superoxide dismutase(SOD) in renal cortex and erythrocytes, the level of lipid peroxidant(LPO)in plasma,renal function and morphology of leftover kidney were examined in rats.The results showed that Huangdan capsule could slow down the increase of BUN and Scr,promote the SOD activity in renal cortex and erythrocytes, reduce the level of LPO in plasma and delay the renal pathological changes in 5/6 nephrectomized rats.The mechanism of Huangdan capsule's antiperoxidant effect, its effect on the renal pathological changes and relationship between the two effects were also discussed.
