Simultaneously achieving room-temperature phosphorescence(RTP) and multiple-stimuli responsiveness in a single-component system is of significance but remains challenging. Crystallization has been recognized to be a w...Simultaneously achieving room-temperature phosphorescence(RTP) and multiple-stimuli responsiveness in a single-component system is of significance but remains challenging. Crystallization has been recognized to be a workable strategy to fulfill the above task. However, how the molecular packing mode affects the intersystem crossing and RTP lifetime concurrently remains unclear so far. Herein, four economic small-molecular compounds, analogues of the famous drug raloxifene(RALO), are facilely synthesized and further explored as neat single-component and stimuli-responsive RTP emitters via crystallization engineering. Thanks to their simple structures and high ease to crystallize, these raloxifene analogues function as models to clarify the important role of molecular packing in the RTP and stimuliresponsiveness properties. Thorough combination of the single-crystal structure analysis and theoretical calculations clearly manifests that the tight antiparallel molecular packing mode is the key point to their RTP behaviors. Interestingly, harnessing the controllable and reversible phase transitions of the two polymorphs of RALO-OAc driven by mechanical force, solvent vapor, and heat, a single-component multilevel stimuli-responsive platform with tunable emission color is established and further exploited for optical information encryption. This work would shed light on the rational design of multi-stimuli responsive RTP systems based on single-component organics.展开更多
目的通过Meta分析对补肾中药改善IVF-ET周期卵巢储备功能和子宫内膜容受性的机制进行科学评价,为临床治疗提供客观研究证据。方法通过检索中国知网(2000—2014)和万方(2000—2014)等数据库有关补肾中药改善IVF患者卵巢储备功能和子宫内...目的通过Meta分析对补肾中药改善IVF-ET周期卵巢储备功能和子宫内膜容受性的机制进行科学评价,为临床治疗提供客观研究证据。方法通过检索中国知网(2000—2014)和万方(2000—2014)等数据库有关补肾中药改善IVF患者卵巢储备功能和子宫内膜容受性的临床随机对照研究文献资料,按照纳入和排除标准选择入选文献资料,使用Rev Man 5.2统计软件进行Meta分析[计数资料采用比值比(Odds Ratio,OR)分析、计量资料采用Mean Diffence分析]分析其95%的置信区间和统计得出的森林图。结果共纳入12篇文献,试验患者均自愿接受补肾中药的治疗,并接受IVF术。通过对795名患者的获卵数、HCG注射日雌激素水平、受精率、优质胚胎率、子宫内膜厚度、子宫血脉搏动指数、子宫血脉阻力指数、临床妊娠率等数据进行Meta分析,结果显示实验组(补肾中药+西药)对改善IVF-ET周期的卵巢储备功能和子宫内膜容受性的疗效优于对照组(西药)。结论采用补肾中药联合西药治疗的IVF患者,在改善卵巢储备功能和子宫内膜容受性的疗效上明显优于单纯西药治疗。因此,补肾中药的使用可以提高IVF患者的临床妊娠率。由于本Meta分析纳入的文献大部分是Jadad评分为3分的文献,所以支持这一结论的证据有限,期待有更多高质量的临床随机对照试验来进一步证实本研究结果。展开更多
基金supported by the National Natural Science Foundation of China (21788102, 22275055, 22025503, 22220102004, 21875064, and 21790361)Shanghai Science and Technology Commission Basic Project Shanghai Natural Science Foundation (21ZR1417600)+5 种基金Shanghai Municipal Science and Technology Major Project (2018SHZDZX03)the Programme of Introducing Talents of Discipline to Universities (B16017)Shanghai Science and Technology Committee (17520750100)Science and Technology Commission of Shanghai Municipality (21JC1401700)the Fundamental Research Funds for the Central Universitiesthe support of Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization。
文摘Simultaneously achieving room-temperature phosphorescence(RTP) and multiple-stimuli responsiveness in a single-component system is of significance but remains challenging. Crystallization has been recognized to be a workable strategy to fulfill the above task. However, how the molecular packing mode affects the intersystem crossing and RTP lifetime concurrently remains unclear so far. Herein, four economic small-molecular compounds, analogues of the famous drug raloxifene(RALO), are facilely synthesized and further explored as neat single-component and stimuli-responsive RTP emitters via crystallization engineering. Thanks to their simple structures and high ease to crystallize, these raloxifene analogues function as models to clarify the important role of molecular packing in the RTP and stimuliresponsiveness properties. Thorough combination of the single-crystal structure analysis and theoretical calculations clearly manifests that the tight antiparallel molecular packing mode is the key point to their RTP behaviors. Interestingly, harnessing the controllable and reversible phase transitions of the two polymorphs of RALO-OAc driven by mechanical force, solvent vapor, and heat, a single-component multilevel stimuli-responsive platform with tunable emission color is established and further exploited for optical information encryption. This work would shed light on the rational design of multi-stimuli responsive RTP systems based on single-component organics.
文摘目的通过Meta分析对补肾中药改善IVF-ET周期卵巢储备功能和子宫内膜容受性的机制进行科学评价,为临床治疗提供客观研究证据。方法通过检索中国知网(2000—2014)和万方(2000—2014)等数据库有关补肾中药改善IVF患者卵巢储备功能和子宫内膜容受性的临床随机对照研究文献资料,按照纳入和排除标准选择入选文献资料,使用Rev Man 5.2统计软件进行Meta分析[计数资料采用比值比(Odds Ratio,OR)分析、计量资料采用Mean Diffence分析]分析其95%的置信区间和统计得出的森林图。结果共纳入12篇文献,试验患者均自愿接受补肾中药的治疗,并接受IVF术。通过对795名患者的获卵数、HCG注射日雌激素水平、受精率、优质胚胎率、子宫内膜厚度、子宫血脉搏动指数、子宫血脉阻力指数、临床妊娠率等数据进行Meta分析,结果显示实验组(补肾中药+西药)对改善IVF-ET周期的卵巢储备功能和子宫内膜容受性的疗效优于对照组(西药)。结论采用补肾中药联合西药治疗的IVF患者,在改善卵巢储备功能和子宫内膜容受性的疗效上明显优于单纯西药治疗。因此,补肾中药的使用可以提高IVF患者的临床妊娠率。由于本Meta分析纳入的文献大部分是Jadad评分为3分的文献,所以支持这一结论的证据有限,期待有更多高质量的临床随机对照试验来进一步证实本研究结果。
