朴素贝叶斯分类器在化疗所致恶心呕吐风险预测模型上的应用

目的研究朴素贝叶斯分类器在化疗所致恶性呕吐风险预测模型上的应用,构建基于中国患者的化疗所致恶性呕吐风险预测模型。方法收集2020年7~9月中南大学湘雅二医院肿瘤中心300例住院化疗患者的基本资料和治疗方案,并随访患者出院后临床资料。对治疗方案中的特征和患者个体特征进行相关性分析,对相关性大于0.8的两个特征,分别计算两个特征对模型评价指标曲线下面积的贡献,去除其中贡献相对较小的特征。使用机器学习库scikit-learn中的朴素贝叶斯分类器作为化疗所致恶心呕吐风险预测模型,使用10折分层随机分割交叉验证得到模型最终结果。其中70%的样本用来训练机器学习模型,30%的样本作为测试集用来衡量模型的表现。结果急性化疗所致恶心呕吐风险预测灵敏度为0.83±0.04(95%CI:0.80~0.86),特异度为0.45±0.03(95%CI:0.42~0.47),曲面下面积为0.72±0.04(95%CI:0.69~0.75)。延迟性化疗所致恶心呕吐风险预测灵敏度为0.84±0.01(95%CI:0.83~0.86),特异度为0.48±0.03(95%CI:0.45~0.52),曲面下面积为0.74±0.02(95%CI:0.72~0.77)。结论在本研究中,基于朴素贝叶斯分类器构建了适用于中国肿瘤患者的化疗致所致恶心呕吐风险预测模型,具有较好的预测效果,为化疗致所致恶心呕吐风险预测模型提供新的研究方向和思路。

Observation of e^+e^-→D_s^+■^((*)0)K^- and study of the P-wave D_s mesons

Studies of e^+e~→D_s^+■^((*)0)K^-and the P-wave charmed-strange mesons are performed based on an e^+e^-collision data sample corresponding to an integrated luminosity of 567 pb^(-1) collected with the BESIII detector at s^(1/2)=4.600 GeV. The processes of e^+e^-→D_s^+■^(*0)K^- and D_s^+■~0K^- are observed for the first time and are found to be dominated by the modes D_s^+D_(s1)(2536)^-and D_s^+D_(s2)~*(2573)^-, respectively. The Born cross sections are measured to be σ~B(e^+e^-→D_s^+■^(*0)K^-) =(10.1±2.3±0.8) pb and σ~B(e^+e^-→D_s^+■~0K^-) =(19.4±2.3± 1.6) pb, and the products of Born cross section and the decay branching fraction are measured to be σ~B(e^+e^-→D_s^+D_(s1)(2536)^-+c.c.)·B(D_(s1)(2536)^-→■^(*0)K^-)=(7.5±1.8±0.7) pb and σ~B(e^+e^-→D_s^+D_(s2)~*(2573)^-+ c.c.)·B(D_(s2)~*(2573)^-→■~0 K^-)=(19.7 ± 2.9 ±2.0) pb. For the D_(s1)(2536)^-and D_(s2)~*(2573)^-mesons, the masses and widths are measured to be M(D_(s1)(2536)^-)=(2537.7±0.5 ±3.1) MeV/c2, Γ(D_(s1)(2536)^-) =(1.7 ±1.2 ±0.6)MeV, and M(D_(s2)~*(2573)^-)=(2570.7±2.0 ±1.7) MeV/c^2, Γ(D_(s2)~*(2573)^-)=(17.2 ±3.6 ±1.1) MeV. The spin-parity of the D_(s2)~*(2573)^-meson is determined to be J^p= 2^+. In addition, the processes e^+e^-→D_s^+■^((*)0)K^-are searched for using the data samples taken at four(two) center-of-mass energies between 4.416(4.527) and 4.575 GeV, and upper limits at the 90% confidence level on the cross sections are determined.

Evidence for the decays of ∧_c^+→∑^+η and ∑^+η’

We study the hadronic decays of ∧c^+ to the final states ∑^+η and ∑^+η, using an e^+e^- annihilation data sample of 567 pb^-1 taken at a center-of-mass energy of 4.6 GeV with the BESIII detector at the BEPCII collider. We find evidence for the decays ∧^+→∑^+η and ∑^+η' and with statistical significance of and , respectively. Normalizing to the reference decays ∧^+→∑^+π^0 and ∑^+ω, we obtain the ratios of the branching fractions B(∧C^+→∑^+η)/V(∧^→∑^+π^0)and B(∧C^+→∑^+η)/B(∧C^+→∑^+ω)to be and , respectively. The upper limits at the 90% confidence level are set to be B(∧C^→∑^+η)/V(∧^+→∑^+π^0)<0.58 and B(∧C^+→∑^+η)/B(∧C^+→∑^+ω)<1.2. Using BESIII measurements of the branching fractions of the reference decays, we determine B(∧C^+→∑^+η)=(0.41±019±0.05)%(<0.68%) and B(∧C^+→∑^+η)=(1.34+0.53+0.19)%(<1.9%). Here, the first uncertainties are statistical and the second systematic. The obtained branching fraction of ∧C^+→∑^+η is consistent with the previous measurement, and the branching fraction of ∧C^+→∑^+η is measured for the first time.

Measurement of e^+e^-→D■ cross sections at the ψ(3770) resonance

We report new measurements of the cross sections for the production of DD final states at theψ（3770）resonance.Our data sample consists of an integrated luminosity of 2.93 fb^（-1）of e~＋e^-annihilation data produced by the BEPCⅡ collider and collected and analyzed with the BESⅢ detector.We exclusively reconstruct three D^0and six D~＋hadronic decay modes and use the ratio of the yield of fully reconstructed DD events（“double tags”）to the yield of all reconstructed D or D mesons（“single tags”）to determine the number of D^0 D^0and D~＋D^-events,benefiting from the cancellation of many systematic uncertainties.Combining these yields with an independent determination of the integrated luminosity of the data sample,we find the cross sections to beσ（e~＋e^-→D^0D^0）=（3.615±0.010±0.038）nb andσ（e~＋e^-→D~＋D^-）=（2.830±0.011±0.026）nb,where the uncertainties are statistical and systematic,respectively.

Tuning and validation of hadronic event generator for R value measurements in the tau-charm region

To measure the R value in an energy scan experiment with e＋e- collisions, precise calculation of initial state radiation is required in the event generators. We present an event generator for this consideration, which incorporates initial state radiation effects up to second order accuracy. The radiative correction factor is calculated using the totally hadronic Born cross section. The measured exclusive processes are generated according to their cross sections, while the unknown processes are generated using the LUND Area Law model, and its parameters are tuned with data collected at s = 3.65 GeV. The optimized values are validated with data in the range s = 2.2324--3.671 GeV. These optimized parameters are universally valid for event generation below the DIS threshold.

Measurement of the integrated Luminosities of cross-section scan data samples around theψ(3770)mass region

To investigate the nature of the Ψ（3770） resonance and to measure the cross section for e^＋e^-→DD, a cross-section scan data sample, distributed among 41 center-of-mass energy points from 3.73 to 3.89 GeV, was taken with the BESIII detector operated at the BEPCII collider in the year 2010. By analyzing the large angle Bhabha scattering events, we measure the integrated luminosity of the data sample at each center-of-mass energy point. The total integrated luminosity of the data sample is 76.16±0.04±0.61 pb^-1, where the first uncertainty is statistical and the second systematic.