基金supported by the National Key Research and Development Program of China(2022YFC2403200)the National Natural Science Foundation of China(52221006,52293382,52122304,and 52073024)+1 种基金the National High Level Hospital Clinical Research Funding(2023-NHLHCRF-YGJH-ZR-02)Beijing Outstanding Young Scientist Program(BJJWZYJH01201910010024)。